A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer
A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer
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DOI：
10.1016/j.tetlet.2008.09.052
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发表时间：
2008-11-17
影响因子：
1.8
通讯作者：
Callan, John F.
中科院分区：
文献类型：
--
作者：
Singh, Narinder;Kaur, Navneet;Callan, John F.
在pH 7.0的半水溶液中，研制了一种简单的荧光传感器，用于比率识别Mg ~（2+）。该传感器，席夫碱，经历激发态分子内质子转移（ESIPT），以产生具有熟练的Mg 2+结合能力的酮互变异构体。该传感器对包括碱金属/碱土金属离子在内的其它金属离子显示出良好的选择性，并且可以测量2.0和30.0 μ M之间的Mg 2+离子浓度。结合化学计量确定为2：1（主体：客体），缔合常数（K-21）为（1.4 +/- 0.1）x 10（4）m（-2）。该传感器可能用于检测高镁血症等疾病。(C)2008爱思唯尔有限公司保留所有权利。
A simple fluorescent sensor has been developed for the ratiometric recognition of Mg2+ in semi-aqueous solution at pH 7.0. The sensor, a Schiff base, undergoes Excited State Intramolecular Proton Transfer (ESIPT) to generate a keto tautomer with proficient Mg2+ binding capability. The sensor displays good selectivity over other metal ions including alkali/alkali earth ions and can measure Mg2+ ion concentration between 2.0 and 30.0 mu M. The binding stoichiometry was established as 2:1 (host:guest) with an association constant (K-21) of (1.4 +/- 0.1) x 10(4) m(-2). The sensor could potentially be used to detect conditions such as hypermagnesaemia. (C) 2008 Elsevier Ltd. All rights reserved.