BIOLOGICAL ROLE FOR MAJOR HISTOCOMPATIBILITY ANTIGENS
BIOLOGICAL ROLE FOR MAJOR HISTOCOMPATIBILITY ANTIGENS
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DOI：
10.1016/s0140-6736(75)92610-0
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发表时间：
1975-01-01
期刊：
影响因子：
168.9
通讯作者：
ZINKERNAGEL, RM
中科院分区：
文献类型：
--
作者：
DOHERTY, PC;ZINKERNAGEL, RM
主要的组织相容性(H)抗原的核心功能可能是向免疫系统发出自身变化的信号。病毒诱导的强大移植抗原的修饰明显导致胸腺来源的淋巴细胞(T细胞)识别，随后克隆扩增和免疫消除带有非自我决定因素的细胞。在高等脊椎动物主要H抗原系统中发现的极端遗传多态可能反映了这种免疫监测机制所施加的进化压力。
A central function of the major histo-compatibility (H) antigens may be to signal changes in self to the immune system. Virus-induced modification of strong transplantation antigens apparently results in recognition by thymus-derived lymphocytes (T cells), with subsequent clonal expansion and immune elimination of cells bearing non-self determinants. The extreme genetic polymorphism found in the major H antigen systems of higher vertebrates may reflect evolutionary pressure exerted by this immunological surveillance mechanism.