THE STONEHOUSE SURVEY - NASOPHARYNGEAL CARRIAGE OF MENINGOCOCCI AND NEISSERIA-LACTAMICA
THE STONEHOUSE SURVEY - NASOPHARYNGEAL CARRIAGE OF MENINGOCOCCI AND NEISSERIA-LACTAMICA
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DOI：
10.1017/s0950268800066449
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发表时间：
1987-12-01
影响因子：
4.2
通讯作者：
NOAH, ND
中科院分区：
文献类型：
--
作者：
CARTWRIGHT, KAV;STUART, JM;NOAH, ND
1986年11月，在格洛斯特郡斯通豪斯（Stonehouse）人口调查期间，作为对脑膜炎球菌病爆发调查的一部分，共收集了6234份鼻咽拭子。总脑膜炎球菌携带率为10.9%。乘车率随着年龄的增长而上升，从0- 4岁的2.1%上升到15- 19岁的24.5%，之后随着年龄的增长而稳步下降。男性携带脑膜炎球菌的人数比女性携带脑膜炎球菌的人数多3:2。从1.4%的受试者中分离出引起暴发的B组（或不可分组）15型磺胺耐药菌株。这些菌株携带者的年龄分布与其他脑膜炎球菌相似，除了在5-9岁年龄组中有一个额外的高峰，并且随着年龄的增长携带率下降得更快。在不同学校就读的儿童和该镇不同地区的居民中，发现爆发菌株的携带率存在差异。在长期暴发期间，这些菌株在社区中的低携带率支持了这样一种假设，即这些生物体的传染性较低，但毒性比其他致病性脑膜炎球菌菌株更强。内酰胺奈瑟菌的携带被认为对脑膜炎球菌免疫的发展很重要，在5岁以下儿童中最为常见，在这一年龄组中比脑膜炎奈瑟菌携带常见6倍。因此，儿童和成人女性内酰胺乳杆菌携带者的数量日益超过男性，而脑膜炎球菌携带者的数量则以男性为主。
A total of 6234 nasopharyngeal swabs was collected during a survey of the population of Stonehouse, Gloucestershire in November 1986 as part of an investigation into an outbreak of meningococcal disease. The overall meningococcal carriage rate was 10.9%. The carriage rate rose with age from 2.1% in the 0- to 4-year-olds to a peak of 24.5% in the 15- to 19-year-olds, and thereafter declined steadily with age. Male carriers outnumbered female carriers of meningococci by 3:2. Group B (or non-groupable) type 15 sulphonamide-resistant strains which had caused the outbreak were isolated from 1.4% of subjects. The age distribution of carriers of these strains was similar to that of other meningococci apart from an additional peak in the 5-9-year age group and a more rapid decline in carriage with increasing age. Variations in the carriage rates of the outbreak strain were seen in children attending different schools and in the residents of different areas of the town. The low carriage rate of these strains in a community during a prolonged outbreak supports the hypothesis that these organisms are less transmissible but more virulent than other strains of pathogenic meningococci. Carriage of Neisseria lactamica, which is thought to be important in the development of meningococcal immunity, was most frequent in children under the age of 5 years and was six times commoner in this age group than carriage of Neisseria meningitidis. In order children and adults female carriers of N. lactamica increasingly outnumbered males in contrast to the male preponderance observed with meningococcal carriage.