Challenges and Opportunities in Antimicrobial Stewardship among Hematopoietic Stem Cell Transplant and Oncology Patients.

Challenges and Opportunities in Antimicrobial Stewardship among Hematopoietic Stem Cell Transplant and Oncology Patients.
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DOI:
10.3390/antibiotics12030592
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发表时间:
2023-03-16
期刊:
影响因子:
4.8
通讯作者:
Bhatt, Pinki J.
Bhatt, Pinki J.
中科院分区:
医学3区
文献类型:
--
作者:
Majumdar, Anjali;Shah, Mansi R.;Park, Jiyeon J.;Narayanan, Navaneeth;Kaye, Keith S.;Bhatt, Pinki J.

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在多重耐药性日益严重的时代,抗菌药物管理计划在优化抗菌药物对病原体的使用方面发挥着关键作用。然而,在造血干细胞移植和肿瘤人群中实施抗菌药物管理计划带来了挑战,因为宿主人群中存在多种风险因素以及影响他们的感染。考虑到潜在的免疫抑制和不良结局的较高风险,这些患者的治疗决定。在这篇多学科的观点文章中,我们总结了当前抗菌药物管理的现状,独特的挑战以及这些患者人群未满足需求的机会。
Antimicrobial stewardship programs play a critical role in optimizing the use of antimicrobials against pathogens in the era of growing multi-drug resistance. However, implementation of antimicrobial stewardship programs among the hematopoietic stem cell transplant and oncology populations has posed challenges due to multiple risk factors in the host populations and the infections that affect them. The consideration of underlying immunosuppression and a higher risk for poor outcomes have shaped therapeutic decisions for these patients. In this multidisciplinary perspective piece, we provide a summary of the current landscape of antimicrobial stewardship, unique challenges, and opportunities for unmet needs in these patient populations.
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