Enhancement of amphetamine-induced locomotor activity and dopamine release in nucleus accumbens following excitotoxic lesions of the hippocampus
Enhancement of amphetamine-induced locomotor activity and dopamine release in nucleus accumbens following excitotoxic lesions of the hippocampus
复制标题
海马兴奋性毒性损伤后安非他明诱导的运动活性和伏核多巴胺释放的增强
DOI：
10.1016/0166-4328(93)90110-c
复制
发表时间：
1993
影响因子：
2.7
通讯作者：
T. Robbins
中科院分区：
文献类型：
--
作者：
L. Wilkinson;G. Mittleman;E. Torres;T. Humby;F. Hall;T. Robbins
本研究使用行为学和神经化学证据检验了海马体调节多巴胺依赖的丘脑核功能的假设。秋水仙碱和红藻氨酸诱导的海马双侧病变的大鼠表现出同等水平的自发活动，但增强的活动过度产生的，剂量依赖性，由D-安非他明测量光电池活动笼。相同的大鼠随后接受单方面的微透析探针，目的是在延髓核，并显示细胞外多巴胺水平升高的反应D-苯丙胺，但没有显着差异的基础值与假手术对照组相比。结果进行了讨论，在涉及中脑边缘多巴胺释放的控制海马和神经核之间的功能相互作用。
This study tested the hypothesis that the hippocampus modulates dopamine-dependent function of the nucleus accumbens using behavioural and neurochemical evidence. Rats with bilateral lesions of the hippocampus induced by colchicine and kainic acid exhibited equivalent levels of spontaneous locomotor activity but a potentiation of the hyperactivity produced, dose-dependently, by D-amphetamine measured in photocell activity cages. The same rats subsequently received unilateral implantations of a microdialysis probe aimed at the nucleus accumbens and showed elevated levels of extracellular dopamine in response to D-amphetamine but no significant difference in basal values in comparison with sham-operated controls. The results are discussed in terms of functional interactions between the hippocampus and nucleus accumbens involving the control of mesolimbic dopamine release.