ERADICATION OF TUBERCULOSIS INFECTION BY ISONIAZID CHEMOPROPHYLAXIS
ERADICATION OF TUBERCULOSIS INFECTION BY ISONIAZID CHEMOPROPHYLAXIS
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DOI：
10.1080/00039896.1968.10665013
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发表时间：
1968-01-01
期刊：
影响因子：
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通讯作者：
BAKER, JH
中科院分区：
文献类型：
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作者：
HOUK, VN;KENT, DC;BAKER, JH
结果在研究期间，有179人从先前已知的5tu PPD阴性状态转变为5tu PPD- s阳性反应（大于10从硬化）。还确定了另外24个已知的结核菌素反应器并用于比较。表1描述了异烟肼化学预防期间皮肤试验随后恢复为阴性的百分比。术语“结核菌素皮肤试验敏感性逆转”是指在随后的重新测试中，除了先前对纯化蛋白衍生物- battey （PPD-B）或纯化蛋白衍生物- gause （PPD-G）敏感的个体外，没有显示出硬化。在后一组中，如果对PPD-G的反应超过10 mm，则认为皮肤对PPDS从0到8 mm硬化的敏感性为阴性。然而，大多数这样的负面反应，包括个体对PPD-S的反应为0毫米或0至4毫米，当对PPD-G的反应被证明。感染的实际日期尚不清楚。对于表1中的基团，转换发生在列出的时间段内，因为这是已知无反应性和已知反应性到5 TU PPD-S之间的间隔。有45人皈依了宗教
ResultsDuring the period of study there were 179 individuals who converted from a prior known negative tuberculin status when tested with 5 TU PPD to a positive reaction (greater than 10 rom induration) when retested with 5 TU PPD-S. Twenty-four additional known tuberculin reactors were also identified and used for comparison. Table 1 depicts percentages of subsequent reversion to negative skin test during isoniazid chemoprophylaxis. The term" reversion of tuberculin skin test sensitivity" is used to mean that on subsequent retesting no induration was demonstrated except in those individuals who had had previous sensitivity to purified protein derivative-Battey (PPD-B) or purified protein derivative-Gause (PPD-G). In the latter group, skin sensitivity to PPDS from 0 to 8 mm induration was considered negative if the reaction to PPD-G was in excess of 10 mm. The majority of such negative reactions, however, included individuals whose reaction was 0 mm or was 0 to 4 mm to PPD-S when reactivity to PPD-G was demonstrated.The actual date of infection is unknown. For the groups in Table 1, conversion occurred within the period of time listed, since that is the interval between known nonreactivity and known reactivity to 5 TU PPD-S. There were 45 who had converted