INDUCTION OF MAMMARY-TUMORS BY EXPRESSION OF POLYOMAVIRUS MIDDLE T-ONCOGENE - A TRANSGENIC MOUSE MODEL FOR METASTATIC DISEASE
INDUCTION OF MAMMARY-TUMORS BY EXPRESSION OF POLYOMAVIRUS MIDDLE T-ONCOGENE - A TRANSGENIC MOUSE MODEL FOR METASTATIC DISEASE
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DOI：
10.1128/mcb.12.3.954
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发表时间：
1992-03-01
影响因子：
5.3
通讯作者：
MULLER, WJ
中科院分区：
文献类型：
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作者：
GUY, CT;CARDIFF, RD;MULLER, WJ
通过建立在小鼠乳腺肿瘤病毒启动子/增强子转录控制下携带多瘤病毒中T癌基因的转基因小鼠品系，研究了多瘤病毒中T抗原在乳腺特异性表达的效应。与大多数携带激活癌基因的转基因品系不同，多瘤病毒中T抗原的表达导致乳腺上皮广泛转化，并迅速产生多灶性乳腺腺癌。有趣的是，大多数患肿瘤的转基因小鼠在肺部发生继发性转移性肿瘤。综上所述，这些结果表明中T抗原在乳腺上皮中是一种强效癌基因，并且表达它的细胞具有增强的转移潜能。
The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential.