Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance
Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance
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DOI：
10.1016/j.neuroimage.2005.12.001
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发表时间：
2006-05-15
期刊：
影响因子：
5.7
通讯作者：
Dinges, David F.
中科院分区：
文献类型：
--
作者：
Chee, Michael W. L.;Chuah, Lisa Y. M.;Dinges, David F.
对26名健康青年在正常睡眠后、24和35小时睡眠剥夺（SD）后的工作记忆进行了评估，以研究个体间表现差异的神经相关因素。性能下降的程度在两个SD测试期间没有显着差异，尽管在SD35时性能有更大的变化。在两次SD睡眠中，顶叶上区和左丘脑的任务相关激活（相对于正常睡眠）都减少了。正常睡眠后左顶叶和左额叶区域的激活与从正常睡眠到SD24的工作记忆准确性下降呈负相关，从而区分了在SD后保持工作记忆表现的人和易受其影响的人。(c) 2005爱思唯尔公司版权所有。
Working memory was evaluated after normal sleep, and at 24 and 35 h of sleep deprivation (SD) in 26 healthy young adults to examine the neural correlates of inter-individual differences in performance. The extent of performance decline was not significantly different between the two SD test periods although there was greater variability in performance at SD35. In both SD sessions, there was reduced task-related activation (relative to normal sleep) in both superior parietal regions and the left thalamus. Activation of the left parietal and left frontal regions after normal sleep was negatively correlated with performance accuracy decline from normal sleep to SD24 thus differentiating persons who maintained working memory performance following SD from those who were vulnerable to its effects. (c) 2005 Elsevier Inc. All rights reserved.