The Demography and Etiology of Pediatric Enucleation in a Tertiary Eye Center in North China, 2001-2015
The Demography and Etiology of Pediatric Enucleation in a Tertiary Eye Center in North China, 2001-2015
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2001-2015年华北地区某三级眼科中心儿童剜除术的人口学及病因分析
DOI：
10.1080/09286586.2018.1523439
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发表时间：
2019
影响因子：
1.8
通讯作者：
Dai Yunhai
中科院分区：
文献类型：
--
作者：
Zhang Jing;Wan Lei;Dai Yunhai
目的：回顾山东省眼科研究所2001年1月至2015年12月收治的0~14岁儿童眼科住院患者的人口学特征及病因。对2001~2005年、2006~2010年、2011~2015年3个时段的变化进行对比分析。结果：共收集儿科住院患者9307例。对71例(71眼)眼球摘除患者进行分析，其中男46例(64.79%)，女25例(35.21%)。眼球摘除时平均年龄9岁(0~14岁)。这15年间，儿童摘眼率为0.76%(71/9307)，呈下降趋势(P<；0.001)。2001年至2005年，这一数字为3.45%(43/1245)；2006年至2010年下降至0.80%(26/3231)，到2015年进一步下降至0.04%(2/4831)。创伤(52.1%，37/71)是主要病因。总体而言，89.2%(33只眼)有开放性眼球损伤，其中78.4%(29/37)为男孩。开放性损伤患者伤时平均年龄6.0岁(0~14岁)，眼球摘除时平均年龄11岁(2~14岁)。视网膜母细胞瘤(RB)(22.5%，16/71)是第二位常见的病因，其中68.8%(11/16)的病例为女孩，平均年龄为2(0-5)岁。结论：随着时间的推移，中国北部，特别是山东省，儿童视网膜母细胞瘤摘除的病例有所减少，这可能是由于手术技术的改进、RB治疗的改进以及儿童公共卫生干预的结果。
Purpose: To review the demography and etiology of pediatric enucleation over time.Methods: Pediatric ophthalmic inpatients recruited and recorded (aged 0–14 years) at Shandong Eye Institute from January 2001 to December 2015 were reviewed. Changes during the three periods from 2001 to 2005, 2006 to 2010, and 2011 to 2015 were compared and analyzed.Results: A total of 9307 pediatric inpatients were reviewed. Of these, 71 patients (71 eyes) who had been treated by enucleation were analyzed; 46 were boys (64.79%) and 25 were girls (35.21%). The mean age at enucleation was 9 (0–14) years. The pediatric enucleation rate during this 15-year period was 0.76% (71/9307), with a decreasing trend (p< 0.001). From 2001 to 2005, the figure was 3.45% (43/1245); it dropped to 0.80% (26/3231) from 2006 to 2010 and then dropped further to 0.04% (2/4831) by 2015. Trauma (52.1%, 37/71) was the leading etiology. Overall, 89.2% (33 eyes) exhibited open globe injuries; 78.4% (29/37) of these involved boys. In the cases with open injuries, the mean age at the time of trauma was 6.0 (0–14) years and the mean age at enucleation was 11 (2–14) years. Retinoblastoma (RB) (22.5%, 16/71) was the second-most common etiology; 68.8% (11/16) of these cases involved girls and the mean age at enucleation was 2 (0–5) years.Conclusion: A decrease in pediatric enucleation in North China, especially in Shandong Province, was observed over time, possibly because of better surgical techniques, improvements in the treatment of RB, and public health interventions in children.