Detection of the new SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in five SARS-CoV-2 rapid antigen tests (RATs), Germany, March 2021.

Detection of the new SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in five SARS-CoV-2 rapid antigen tests (RATs), Germany, March 2021.
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DOI：
10.2807/1560-7917.es.2021.26.16.2100413
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发表时间：
2021-04
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
通讯作者：
Bavarian SARS-CoV-Public Health Laboratory Team
Bavarian SARS-CoV-Public Health Laboratory Team
中科院分区：
其他
文献类型：
--
作者：
Jungnick S;Hobmaier B;Mautner L;Hoyos M;Haase M;Baiker A;Lahne H;Eberle U;Wimmer C;Hepner S;Sprenger A;Berger C;Dangel A;Wildner M;Liebl B;Ackermann N;Sing A;Fingerle V;Bavarian SARS-CoV-2-Public Health Laboratory Team;Bavarian SARS-CoV-Public Health Laboratory Team
来源链接：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063588/

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SARS-CoV-2变异的关注（VOC）不应该逃脱分子监测。我们研究了SARS-CoV-2快速抗原检测（RAT）是否可以在某些实验室条件下检测B.1.1.7和B.1.351 VOCs。将含有B.1.1.7、B.1.351或非VOC SARS-CoV-2的感染性细胞培养上清液分别稀释于DMEM和唾液中。使用Roche、Siemens、Abbott、nal von明登和RapiGEN RAT分析稀释液。虽然需要使用适当的实际临床样本进行进一步研究，但所有RAT均检出B.1.1.7和B.1.351，通常与非VOC菌株相当。
SARS-CoV-2 variants of concern (VOC) should not escape molecular surveillance. We investigated if SARS-CoV-2 rapid antigen tests (RATs) could detect B.1.1.7 and B.1.351 VOCs in certain laboratory conditions. Infectious cell culture supernatants containing B.1.1.7, B.1.351 or non-VOC SARS-CoV-2 were respectively diluted both in DMEM and saliva. Dilutions were analysed with Roche, Siemens, Abbott, nal von minden and RapiGEN RATs. While further studies with appropriate real-life clinical samples are warranted, all RATs detected B.1.1.7 and B.1.351, generally comparable to non-VOC strain.