A series of N-(2-phenylethyl)nitroaniline derivatives as precursors for slow and sustained nitric oxide release agents.
A series of N-(2-phenylethyl)nitroaniline derivatives as precursors for slow and sustained nitric oxide release agents.
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一系列 N-(2-苯乙基)硝基苯胺衍生物，作为缓慢和持续的一氧化氮释放剂的前体。
DOI：
10.1107/s0108270113025869
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kirschbaum,Kristin
中科院分区：
文献类型：
--
作者：
Wade,ColinB;Mohanty,DillipK;Squattrito,PhilipJ;Amato,NicholasJ;Kirschbaum,Kristin
2,4-Dinitro-N-(2-phenylethyl)aniline, C14H13N3O4, (I), crystallizes with one independent molecule in the asymmetric unit. The adjacent amine and nitro groups form an intramolecular N—H⋯O hydrogen bond. The anti conformation about the ethyl C—C bond leads to the phenyl and aniline rings being essentially parallel. Molecules are linked into dimers by intermolecular N—H⋯O hydrogen bonds, such that each amine H atom participates in a three-centre interaction with two nitro O atoms. Though the dimers pack so that the arene rings of adjacent molecules are parallel, the rings are staggered and π–π interactions do not appear to be favoured. 4,6-Dinitro-N,N′-bis(2-phenylethyl)benzene-1,3-diamine, C22H22N4O4, (II), differs from (I) in the presence of a second 2-phenylethylamine group on the substituted ring. Compound (II) also crystallizes with one unique molecule in the asymmetric unit. Both amine groups are involved in intramolecular N—H⋯O hydrogen bonds with adjacent nitro groups. Although one ethyl group adopts an anti conformation as in (I), the other is gauche, with the result that the pendant phenyl rings are not parallel. The amine group that is part of the gauche conformation participates in a three-centre N—H⋯O hydrogen bond with the nitro group of a neighbouring molecule, leading to dimers as in (I). The other amine H atom does not form any intermolecular hydrogen bonds. The packing leads to separations of ca 3.4 Å of the parallel anti phenyl and aminobenzene rings. 2-Cyano-4-nitro-N-(2-phenylethyl)aniline, C15H13N3O2, (III), differs from (I) only in having a cyano group in place of the 2-nitro group. The absence of the adjacent nitro group eliminates the intramolecular N—H⋯O hydrogen bond. Molecules of (III) adopt the same anti conformation about the ethyl group as in (I), but crystallize in the higher-symmetry monoclinic space group P21/n. The molecules are linked into dimers via N—H⋯N amine–cyano hydrogen bonds, while the nitro groups are not involved in any N—H⋯O interactions. Owing to the different symmetry, the molecules pack in a herringbone pattern with fewer face-to-face interactions between the rings. The closest such interactions are about 3.5 Å between rings that are largely slipped past one another. 4-Methylsulfonyl-2-nitro-N-(2-phenylethyl)aniline, C15H16N2O4S, (IV), differs from (I) in having a methylsulfonyl group in place of the 4-nitro group. The intramolecular N—H⋯O hydrogen bond is present as in (I). However, unlike (I), the conformation about the ethyl group is gauche, so the two arene rings are nearly perpendicular rather than parallel. The packing is significantly different from the other three structures in that there are no intermolecular hydrogen bonds involving the N—H groups. The molecules are arranged in tetragonal columns running along the c axis, with the aniline rings mostly parallel and separated by ca 3.7 Å. Taken together, these structures demonstrate that modest changes in functional groups cause significant differences in molecular conformation, intermolecular interactions and packing.
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影响因子：
5.2
作者：
Williams DE;Dalisay DS;Patrick BO;Matainaho T;Andrusiak K;Deshpande R;Myers CL;Piotrowski JS;Boone C;Yoshida M;Andersen RJ
通讯作者：
Andersen RJ
DOI：
10.1016/j.bbrc.2014.05.087
发表时间：
2014-07-18
影响因子：
3.1
作者：
Curtis, Brandon M.;Leix, Kyle Alexander;Ji, Yajing;Glaves, Richard Samuel Elliot;Ash, David E.;Mohanty, Dillip K.
通讯作者：
Mohanty, Dillip K.
N,N-二乙基-4-硝基苯-1,3-二胺、2,6-双(乙氨基)-3-硝基苯甲腈和双(4-乙氨基-3-硝基苯基)砜。
DOI：
--
发表时间：
2010
期刊：
Acta Crystallographica Section C: Crystal Structure Communications
影响因子：
--
作者：
Thomas J Payne;Chad R. Thurman;Hao Yu;Qian Sun;D. Mohanty;P. J. Squattrito;Mark R Giolando;Christopher R. Brue;K. Kirschbaum
通讯作者：
K. Kirschbaum
影响因子：
37.8
作者：
Stasch JP;Pacher P;Evgenov OV
通讯作者：
Evgenov OV
一氧化氮在健康和疾病中的作用：关注高血压和心血管疾病
DOI：
--
发表时间：
2006
期刊：
The Journal of Clinical Hypertension
影响因子：
--
作者：
T. Giles
通讯作者：
T. Giles