Paget disease: when to treat and when not to treat
Paget disease: when to treat and when not to treat
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佩吉特病：何时治疗和何时不治疗
DOI：
--
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发表时间：
2009
影响因子：
33.7
通讯作者：
F. Singer
中科院分区：
文献类型：
--
作者：
F. Singer
佩吉特骨病是一种可影响一根或多根骨头的局灶性骨骼疾病。许多患者由于血清碱性磷酸酶活性升高或旨在评估不相关病症的骨骼X光片异常而被意外发现。患者通常无症状，但有一部分患者发病率相当高，包括骨痛和骨骼畸形，以及各种区域并发症，例如与颅骨受累相关的听力损失、髋部或膝部退行性关节炎、下肢骨折，以及罕见的肉瘤或巨细胞瘤。双膦酸盐已被证明可以有效控制疾病活动，因为它们抑制破骨细胞功能。施用这些药物可以缓解骨痛，减少骨吸收和骨形成的生化标志物，并延缓或逆转疾病的早期溶骨期。未来的研究需要确定这些药物如果在疾病早期使用，是否可以预防无症状患者的并发症。
Paget disease of bone is a focal disorder of the skeleton that can affect one or more bones. Many patients are discovered accidentally because of elevated serum alkaline phosphatase activity or an abnormal skeletal radiograph intended to evaluate an unrelated condition. Patients are often asymptomatic, but a subset experience considerable morbidity that can include bone pain and skeletal deformity, as well as a variety of regional complications, such as hearing loss associated with cranial involvement, degenerative arthritis of the hip or knee, fractures of the lower extremities and, rarely, sarcoma or giant cell tumors. Bisphosphonates have proven to be effective in controlling disease activity because they inhibit osteoclast function. Administration of these agents can relieve bone pain, decrease biochemical markers of bone resorption and bone formation, and retard or reverse the early osteolytic phase of the disease. Future studies are needed to determine whether these drugs, if used in an early stage of the disease, can prevent complications in asymptomatic patients.
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影响因子：
4.2
作者：
Singer,FR;Mills,BG
通讯作者：
Mills,BG
低剂量硝酸镓治疗晚期佩吉特骨病患者的多中心试验。
DOI：
10.1210/jcem.80.2.7852526
发表时间：
1995
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Bockman,RS;Wilhelm,F;Siris,E;Singer,F;Chausmer,A;Bitton,R;Kotler,J;Bosco,BJ;Eyre,DR;Levenson,D
通讯作者：
Levenson,D
鲑鱼降钙素治疗佩吉特骨病。
影响因子：
--
作者：
Singer,FR;Fredericks,RS;Minkin,C
通讯作者：
Minkin,C
影响因子：
4.1
作者：
Nancollas, G. H.;Tang, R.;Ebetino, F. H.
通讯作者：
Ebetino, F. H.