Platelet aggregation in atopic dermatitis.
Platelet aggregation in atopic dermatitis.
复制标题
特应性皮炎中的血小板聚集。
DOI：
10.1080/09537109975997
复制
发表时间：
1999
期刊：
影响因子：
3.3
通讯作者：
J. Glück
中科院分区：
文献类型：
--
作者：
B. Rogala;J. Gumprecht;J. Glück
许多观察结果表明血小板在过敏性炎症中起积极作用。然而，这个问题在特应性皮炎中的研究很少。本研究的目的是检查特应性皮炎患者血小板聚集的强度和速度以及与某些免疫学参数（总IgE和特异性IgE血清水平）的潜在关系。根据Born方法，在双通道血小板聚集仪中，对12名特应性皮炎患者和12名健康的非特应性患者的血小板聚集进行了评估，以响应三种外源性刺激物（ADP、凝血酶和胶原）。无论使用何种外源性刺激剂，两组之间血小板聚集的强度和速度以及总血小板计数均无差异。与其他特应性疾病相反，特应性皮炎中血小板聚集不受损。
Many observations suggest the active role of platelets in allergic inflammation. However, this problem is poorly researched in atopic dermatitis. The aim of study was to examine the intensity and velocity of platelet aggregation and a potential relationship with some immunological parameters (total IgE and specific-IgE serum levels) in atopic dermatitis patients. Platelet aggregation was evaluated in 12 subjects with atopic dermatitis and 12 healthy, nonatopic persons, according to the Born method, in a dual-channel aggregometer, in response to three exogenous stimulators (ADP, thrombin and collagen). The intensity and velocity of platelet aggregation and total platelet counts did not differ between the two groups irrespective of the type of extrinsic stimulator used. In contrast to other atopic diseases, in atopic dermatitis platelet aggregation is not impaired.