Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT)
Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT)
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DOI：
10.1111/php.13166
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发表时间：
2019-10-22
影响因子：
3.3
通讯作者：
Cengel, Keith A.
中科院分区：
文献类型：
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作者：
Zhu, Timothy C.;Ong, Yihong;Cengel, Keith A.
接受光动力疗法（PDT）的患者的均匀光通量分布对于确保可预测的PDT结果至关重要。然而，当前在输送胸膜内PDT时的实践使用点光源来输送光，该光由放置在胸膜腔内的七个各向同性检测器监测以评估其均匀性。我们开发了一种实时红外（IR）跟踪摄像机，以跟踪光点源的运动和治疗区域的表面轮廓。计算出的光通量率与各向同性检测器匹配，使用两个校正因子的方法和经验模型，包括直接和散射光分量。我们的临床试验表明，我们可以成功地实现红外导航系统在75%（15/20）的患者。在80%（12/15）的患者中成功分析了数据，因为3例患者的探测器位置不可用。我们的结论是，它是可行的，使用基于红外摄像机的系统来跟踪PDT过程中的光源的运动，并证明其使用量化的光分布的均匀性，从规定的光剂量偏离了18%的标准偏差。当获得的光源位置百分比不足时，导航系统将失效（
Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcomes. However, current practice when delivering intrapleural PDT uses a point source to deliver light that is monitored by seven isotropic detectors placed within the pleural cavity to assess its uniformity. We have developed a real-time infrared (IR) tracking camera to follow the movement of the light point source and the surface contour of the treatment area. The calculated light fluence rates were matched with isotropic detectors using a two-correction factor method and an empirical model that includes both direct and scattered light components. Our clinical trial demonstrated that we can successfully implement the IR navigation system in 75% (15/20) of the patients. Data were successfully analyzed in 80% (12/15) patients because detector locations were not available for three patients. We conclude that it is feasible to use an IR camera-based system to track the motion of the light source during PDT and demonstrate its use to quantify the uniformity of light distribution, which deviated by a standard deviation of 18% from the prescribed light dose. The navigation system will fail when insufficient percentage of light source positions is obtained (