Effect of North American ginseng on 137Cs-induced micronuclei in human lymphocytes: a comparison with WR-1065.
Effect of North American ginseng on 137Cs-induced micronuclei in human lymphocytes: a comparison with WR-1065.
复制标题
北美人参对 137Cs 诱导的人淋巴细胞微核的影响：与 WR-1065 的比较。
DOI：
10.1002/ptr.2533
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Diaz,AngelicaL
中科院分区：
文献类型：
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作者：
Lee,Tung-Kwang;Wang,Weidong;O'Brien,KevinF;Johnke,RobertaM;Wang,Tao;Allison,RonR;Diaz,AngelicaL
电离辐射（IR）诱导细胞死亡的主要机制之一是产生攻击细胞DNA的活性氧（ROS）（McBride et al，2004; Moller and Loft，2004; Moulder，2002）。对于接受放疗（RT）的癌症患者，IR诱导的正常组织损伤是一个剂量限制因素（Lee et al，2003; Moulder，2002）。癌症治疗的这一障碍，沿着生物恐怖主义威胁的增加，迫切需要鉴定有效的辐射对策（Moulder，2002; Stone等，2004）。两个最常用的物种，人参CA迈耶（亚洲人参）和西洋参L。（北美人参）因其多重药用生物活性（抗糖尿病、抗癌、解热、镇痛、抗衰老、抗应激和抗疲劳作用）以及促进DNA、RNA和蛋白质合成而引起广泛关注（Attele et al.，1999; Kitts等人，2000; Lee等人，2005年）。此外，由于其有效的抗氧化能力，对亚洲人参的辐射防护作用的研究引起了人们的兴趣，但该研究主要是在动物模型中进行的（Arora等人，2005; Kim等人; 2007; Han等人，2005; Lee等人，2006年; Lee等人，2005年）。我们最近在人外周血淋巴细胞（PBL）中证明了在辐射暴露前24小时应用亚洲人参粗水提取物以剂量依赖性方式预防137 Cs诱导的离体微核（MN）形成的能力（Lee等人）。，2004年a）。这些
One of the major mechanisms of ionizing radiation (IR)-induced cell death is the generation of reactive oxygen species (ROS) that attack cellular DNA (McBride et al, 2004; Moller and Loft, 2004; Moulder, 2002). For cancer patients receiving radiotherapy (RT), IR-induced normal tissue damage is a dose-limiting factor (Lee et al, 2003; Moulder, 2002). This obstacle to cancer treatment, along with the increasing threat of bioterrorism, creates an urgent need for the identification of effective radiation countermeasures (Moulder, 2002; Stone et al, 2004).Ginseng is one of the most frequently purchased herbs in the United States. The two most commonly used species, Panax ginseng CA Meyer (Asian ginseng) and Panax quinquefolius L.(North American ginseng), have drawn widespread attention for their multifold medicinal bioactivities (anti-diabetic, anti-carcinogenic, anti-pyretic, analgesic, antiaging, anti-stress, and anti-fatigue effects), and for their promotion of DNA, RNA, and protein synthesis (Attele et al., 1999; Kitts et al, 2000; Lee et al., 2005). Moreover, because of its effective antioxidant capacity, studies on the radioprotective effects of Asian ginseng have engendered interest, but the research has primarily been done in animal models (Arora et al., 2005; Kim et al; 2007; Han et al., 2005; Lee et al., 2006; Lee et al., 2005). We recently demonstrated in human peripheral blood lymphocytes (PBL) the ability of a crude water extract of Asian ginseng, applied at 24 h before radiation exposure to prevent 137Cs-induced micronuclei (MN) formation ex vivo in a dose-dependent manner (Lee et al., 2004a). These