Antibody Response to SARS-CoV-2 is Associated with Long-term Clinical Outcome in Patients with COVID-19: a Longitudinal Study.
Antibody Response to SARS-CoV-2 is Associated with Long-term Clinical Outcome in Patients with COVID-19: a Longitudinal Study.
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DOI：
10.1007/s10875-021-01083-7
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发表时间：
2021-10
影响因子：
9.1
通讯作者：
Masiá M
中科院分区：
文献类型：
--
作者：
García-Abellán J;Padilla S;Fernández-González M;García JA;Agulló V;Andreo M;Ruiz S;Galiana A;Gutiérrez F;Masiá M
宿主免疫反应和病毒复制与COVID-19患者健康结局的关系仍有待明确。我们的目的是表征COVID-19住院后的中期和长期临床、病毒学和血清学结果，并确定长期covid的预测因素。对经RT-PCR确诊的COVID-19患者进行前瞻性、纵向研究。在住院期间和出院后1、2和6个月采集连续血液和鼻咽样本（NPS），检测SARS-CoV-2 RNA和S-IgG/N-IgG抗体。适当时进行基因组测序。患者在就诊2个月和6个月时填写COVID-19症状问卷（CSQ），并对得分最高的患者进行特征描述。在随访的146例患者中（60%为男性，中位年龄64岁），20.6%需要再次住院，5.5%死亡。在2个月和6个月时，分别有9.6%和7.8%的患者报告了中度/重度持续症状。2个月和6个月时，NPS患者中分别有11.8%（中位Ct = 38）和3%（中位Ct = 36）的SARS-CoV-2 RT-PCR阳性，但未出现再感染。抗体滴度逐渐减弱，在6个月时出现27例（27.6%）N-IgG血清逆转，6例（6%）S-IgG血清逆转。CSQ评分最高的调整后2个月预测因子（OR [95%CI]）为S-IgG峰值较低（0.80[0.66-0.94]）和WHO严重程度评分较高（2.57 [1.20-5.86]）；6个月预测指标为S-IgG峰值较低（0.89[0.79-0.99]）和女性（2.41 [1.20-4.82]）；未发现与病毒RNA脱落时间延长有关。长covid与抗sars - cov -2抗体反应弱、疾病严重程度和女性性别有关。在因COVID-19住院的患者中，有相当大比例出现晚期临床事件和中长期持续症状。在线版本包含补充材料，可在10.1007/s10875-021-01083-7获得。
The relationship of host immune response and viral replication with health outcomes in patients with COVID-19 remains to be defined. We aimed to characterize the medium and long-term clinical, virological, and serological outcomes after hospitalization for COVID-19, and to identify predictors of long-COVID. Prospective, longitudinal study conducted in COVID-19 patients confirmed by RT-PCR. Serial blood and nasopharyngeal samples (NPS) were obtained for measuring SARS-CoV-2 RNA and S-IgG/N-IgG antibodies during hospital stay, and at 1, 2, and 6 months post-discharge. Genome sequencing was performed where appropriate. Patients filled out a COVID-19 symptom questionnaire (CSQ) at 2-month and 6-month visits, and those with highest scores were characterized. Of 146 patients (60% male, median age 64 years) followed-up, 20.6% required hospital readmission and 5.5% died. At 2 months and 6 months, 9.6% and 7.8% patients, respectively, reported moderate/severe persistent symptoms. SARS-CoV-2 RT-PCR was positive in NPS in 11.8% (median Ct = 38) and 3% (median Ct = 36) patients at 2 months and 6 months, respectively, but no reinfections were demonstrated. Antibody titers gradually waned, with seroreversion occurring at 6 months in 27 (27.6%) patients for N-IgG and in 6 (6%) for S-IgG. Adjusted 2-month predictors of the highest CSQ scores (OR [95%CI]) were lower peak S-IgG (0.80 [0.66–0.94]) and higher WHO severity score (2.57 [1.20–5.86]); 6-month predictors were lower peak S-IgG (0.89 [0.79–0.99]) and female sex (2.41 [1.20–4.82]); no association was found with prolonged viral RNA shedding. Long-COVID is associated with weak anti-SARS-CoV-2 antibody response, severity of illness, and female gender. Late clinical events and persistent symptoms in the medium and long term occur in a significant proportion of patients hospitalized for COVID-19. The online version contains supplementary material available at 10.1007/s10875-021-01083-7.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
DOI：
10.1016/s1473-3099(20)30943-9
发表时间：
2021-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Duysburgh E;Mortgat L;Barbezange C;Dierick K;Fischer N;Heyndrickx L;Hutse V;Thomas I;Van Gucht S;Vuylsteke B;Ariën KK;Desombere I
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影响因子：
168.9
作者：
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通讯作者：
Cao, Bin
DOI：
10.1016/s0140-6736(22)02370-4
发表时间：
2023-01-14
期刊：
Lancet (London, England)
影响因子：
--
作者：
The Lancet Editors
通讯作者：
The Lancet Editors
影响因子：
82.9
作者：
Brodin, Petter
通讯作者：
Brodin, Petter