The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults
The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults
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DOI：
10.1210/jc.2003-031398
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发表时间：
2004-03-01
影响因子：
5.8
通讯作者：
Yanovski, JA
中科院分区：
文献类型：
--
作者：
Parikh, SJ;Edelman, M;Yanovski, JA
先前的几份关于小群体的报告发现，与非肥胖白人相比，肥胖白人的血清1，25-二羟基维生素D（1，25-vit D）显着较高。基于这些报告和最近的脂肪细胞体外研究表明，给予1，25-维生素D可以刺激脂肪生成和抑制脂解，一些研究人员提出，高1，25-维生素D可能在促进或维持肥胖成年人脂肪细胞甘油三酯储存中发挥作用。为了验证肥胖通常与1，25-维生素D增加相关的假设，我们在一个大型健康成年人队列中研究了促钙激素与身体肥胖之间的关系。在302名健康成人中测定了吸收后状态下的血清全段PTH、25-羟基维生素D和1，25-维生素D，这些健康成人包括高加索人（n = 190; 71%女性）、非洲裔美国人（n = 84; 89%女性）和其他人种/种族（n = 28; 61%女性）。将154名肥胖受试者[体重指数（BMI）37.3 +/- 5.8 kg/m2;范围30.1 - 58.2 kg/m2]的结果与148名年龄、种族和性别匹配的非肥胖受试者[BMI 25.6 +/- 2.9 kg/m2;范围18.0 - 29.9 kg/m2]的结果进行比较。采用双能X线吸收法测量身体成分。血清全段甲状旁腺素与体质量指数（BMI）（r = 0.42; P< 0.0001）和体脂肪量（r = 0.37; P < 0.0001）呈正相关。血清25-羟维生素D与BMI（r =-0.4; P < 0.0001）和体脂量（r = -0.41; P < 0.0001）呈负相关。血清1，25-维生素D与BMI（r = -0.26; P < 0.0001）和体脂量（r = -0.25; P = 0.0001）呈负相关。在白种人和非裔美国人中，肥胖受试者的血清1，25-vit D显著低于非肥胖受试者（105.7 +/- 41.1 pmol/L vs. 124.8 +/- 36.7 pmol/L; P < 0.0001）。我们的结论是，因为1，25-维生素D浓度下降，随着肥胖的增加，它似乎不太可能在1，25-维生素D的升高是一个重要的激素机制，导致或维持成人肥胖。
Several previous reports of small cohorts have found significantly higher serum 1,25-dihydroxy vitamin D (1,25-vit D) in obese compared with nonobese whites. Based on these reports and on recent in vitro studies of adipocytes which suggest that administration of 1,25-vit D can stimulate lipogenesis and inhibit lipolysis, some investigators have proposed that high 1,25-vit D may play a role in promoting or maintaining adipocyte triglyceride stores in obese adults. To test the hypothesis that obesity is commonly associated with increased 1,25-vit D, we examined the relationships between calciotropic hormones and body adiposity in a large cohort of healthy adults. Serum intact PTH, 25-hydroxy vitamin D, and 1,25-vit D were measured in the postabsorptive state in 302 healthy adults who were Caucasian (n = 190; 71% female), African-American (n = 84; 89% female), and of other race/ethnicity ( n = 28; 61% female). Results from the 154 obese subjects [ body mass index (BMI) 37.3 +/- 5.8 kg/m(2); range, 30.1 - 58.2 kg/m(2)] were compared with those from 148 nonobese (BMI 25.6 +/- 2.9 kg/m(2); range, 18.0 - 29.9 kg/m(2)) age-, race-, and sex-matched participants. Body composition was measured by dual energy x-ray absorptiometry. Serum intact PTH was positively correlated with both BMI (r = 0.42; P< 0.0001) and body fat mass ( r = 0.37; P < 0.0001). Serum 25-hydroxy vitamin D was negatively correlated with BMI (r = - 0.4; P < 0.0001) and body fat mass (r = -0.41; P < 0.0001). Serum 1,25-vit D was also negatively correlated with BMI (r = -0.26; P < 0.0001) and body fat mass (r = -0.25; P = 0.0001). Serum 1,25-vit D was significantly lower in obese than nonobese subjects (105.7 +/- 41.1 vs. 124.8 +/- 36.7 pmol/liter; P < 0.0001) in both Caucasian and African-American adults. We conclude that, because 1,25-vit D concentrations fall with increasing adiposity, it appears unlikely that elevation in 1,25-vit D is an important hormonal mechanism causing or maintaining obesity in adults.