Oral delivery of xeno‐antigen combined with non‐depleting anti‐CD4 monoclonal antibody induces significantly prolonged survival of concordant skin xenograft
Oral delivery of xeno‐antigen combined
with non‐depleting anti‐CD4 monoclonal antibody induces significantly prolonged survival of concordant skin xenograft
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口服异种抗原联合非耗竭抗CD4单克隆抗体可显着延长一致皮肤异种移植物的存活时间
DOI：
10.1034/j.1399-3089.2001.00080.x
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发表时间：
2001
影响因子：
3.9
通讯作者：
S. Kodaira
中科院分区：
文献类型：
--
作者：
M. Niimi;N. Shirasugi;K. Hamano;K. Esato;K. Matsumoto;Y. Ikeda;T. Shatari;H. Takami;S. Kodaira
Abstract: Oral administration can induce unresponsiveness to protein antigens. Therefore, we examined whether oral administration of xeno‐antigen could induce the prolonged survival of xenogeneic skin grafts. CBA mice were given 1 × 107 SD rat splenocytes orally, 7 days before transplantation of a SD rat skin in the presence or absence of a non‐depleting anti‐CD4 monoclonal antibody (mAb) (YTS177, 200 µg/dose, −8 and −7 days relative to transplantation). All skin grafts survived with a median survival time (MST) of 62 days when xeno‐antigens were administered orally in combination with anti‐CD4 mAb. Mice treated with anti‐CD4 mAb alone or oral administration of xeno‐antigen alone induced modest prolonged survival of rat skin grafts (MST = 18 and 19 days, respectively) while naive mice rejected rat skin acutely (MST = 12 days). Oral administration alone or combined with anti‐CD4 mAb reduced the level of xeno‐antibody production compared with that in untreated mice after transplantation. Xenogeneic mixed leukocyte response was reduced when splenocytes from mice pre‐treated with oral administration of xenogeneic cells were used as the responder compared with that in untreated mice. Oral delivery of xeno‐antigen plus non‐depleting anti‐CD4 mAb can induce prolongation of concordant xenogeneic skin grafts.
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实验性自身免疫性葡萄膜视网膜炎的口服耐受。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gregerson,DS;Obritsch,WF;Donoso,LA
通讯作者：
Donoso,LA
DOI：
10.1073/pnas.91.14.6688
发表时间：
1994-07-05
影响因子：
11.1
作者：
FRIEDMAN, A;WEINER, HL
通讯作者：
WEINER, HL
用于治疗自身免疫性疾病的口服耐受。
DOI：
10.1146/annurev.med.48.1.341
发表时间：
1997
期刊：
Annual review of medicine.
影响因子：
--
作者：
Weiner,HL
通讯作者：
Weiner,HL
DOI：
10.1073/pnas.89.1.421
发表时间：
1992-01-01
影响因子：
11.1
作者：
MILLER, A;LIDER, O;WEINER, HL
通讯作者：
WEINER, HL
实验性自身免疫性脑脊髓炎的口服耐受。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Whitacre,CC;Gienapp,IE;Orosz,CG;Bitar,DM
通讯作者：
Bitar,DM