Dopamine and sodium appetite: antagonists suppress sham drinking of NaCl solutions in the rat.
Dopamine and sodium appetite: antagonists suppress sham drinking of NaCl solutions in the rat.
复制标题
多巴胺和钠食欲：拮抗剂抑制大鼠假饮氯化钠溶液。
DOI：
10.1037//0735-7044.111.3.606
复制
发表时间：
1997
影响因子：
1.9
通讯作者：
Bernstein,IL
中科院分区：
文献类型：
--
作者：
Roitman,MF;Schafe,GE;Thiele,TE;Bernstein,IL
钠缺乏的大鼠摄入钠是一种强烈的、有动机的行为，当耗尽的大鼠假饮时，这种行为会进一步增强。多巴胺在动机中起着关键作用，包括与品尝美味相关的奖励。目前的研究评估了多巴胺在利尿剂速尿(10 mg/kg)耗竭钠后真实饮用和假饮用氯化钠溶液中的作用。评估多巴胺(D2)受体拮抗剂(氟哌啶醇[0.1 mg/kg]和拉氯普利[0.2 mg/kg])对2假手术和实际饮用0.3M氯化钠的影响。两种拮抗剂都显着减少了假饮酒，而真正的饮酒并未受到影响。这些影响似乎不是由于不适或抑制运动行为，因为药物处理的动物在给予较低浓度的氯化钠(0.1M)时能够显著增加摄入量。这些结果表明，在耗竭的假饮酒大鼠中，氯化钠刺激的正向兴奋特性是由中枢D2受体介导的。
Sodium (Na) ingestion in rats depleted of Na is a strong, motivated behavior that is enhanced further when depleted rats are sham drinking. Dopamine plays a critical role in motivation, including reward associated with consumption of palatable tastes. The present studies assessed the role of dopamine in real and sham drinking of NaCl solutions after Na depletion with the diuretic furosemide (10 mg/kg). Dopamine (D2) receptor antagonists were evaluated (Haloperidol [0.1 mg/kg] and raclopride [0.2 mg/kg]), for their effects on 2 sham and real drinking of 0.3 M NaCl. Sham drinking was markedly reduced by both antagonists whereas real drinking was unaffected. These effects did not appear to be due to malaise or suppression of motor behavior because drug-treated animals were able to increase ingestion substantially when offered less concentrated NaCl (0.1 M). These results suggest that the positive motivating properties of NaCl stimulation in depleted, sham-drinking rats are mediated by central D2 receptors.(PsycInfo Database Record (c) 2024 APA, all rights reserved)