The brain decade in debate: II. Panic or anxiety? From animal models to a neurobiological basis
The brain decade in debate: II. Panic or anxiety? From animal models to a neurobiological basis
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DOI：
10.1590/s0100-879x2001000200001
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发表时间：
2001-02-01
影响因子：
2.3
通讯作者：
Graeff, FG
中科院分区：
文献类型：
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作者：
Andreatini, R;Blanchard, C;Graeff, FG
这篇文章是由巴西神经科学和行为学会（SBNeC）主办的电子研讨会的转录。来自欧盟、北美和巴西的研究人员就焦虑问题进行了讨论。也就是恐慌是一种非常强烈的焦虑还是别的什么。以及临床焦虑的哪些方面是由动物模型复制的。关于第一个问题，大多数与会者同意，广泛性焦虑和恐慌症是不同的临床表现的基础上。药物反应和动物模型。Also.潜在的大脑结构、神经递质调节和激素变化似乎涉及重要的差异。众所周知，现有的动物模型会产生不同类型的恐惧/焦虑。未来研究的一个挑战是在动物模型和疾病分类之间建立良好的相关性。
This article is a transcription of an electronic symposium sponsored by the Brazilian Society of Neuroscience and Behavior(SBNeC). invited researchers from the European Union, North America and Brazil discussed two issues on anxiety. namely whether panic is a very intense anxiety or something else. and what aspects of clinical anxiety are reproduced by animal models. Concerning the first issue, most participants agreed that generalized anxiety and panic disorder are different on the basis of clinical manifestations. drug response and animal models. Also. underlying brain structures, neurotransmitter modulation and hormonal changes seem to involve important differences. It is also common knowledge that existing animal models generate different types of fear/anxiety. A challenge for future re search is to establish a good correlation between animal models and nosological classification.