Relationship between jaw movements and trigeminal motoneuron membrane-potential fluctuations during cortically induced rhythmical jaw movements in the guinea pig.
Relationship between jaw movements and trigeminal motoneuron membrane-potential fluctuations during cortically induced rhythmical jaw movements in the guinea pig.
复制标题
豚鼠皮质诱导的节律性下颌运动期间下颌运动与三叉神经运动神经元膜电位波动之间的关系。
DOI：
10.1152/jn.1982.48.1.110
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发表时间：
1982
影响因子：
2.5
通讯作者：
Tal,M
中科院分区：
文献类型：
--
作者：
Goldberg,LJ;Chandler,SH;Tal,M
反复观察发现，对实验动物的面部或运动皮层咀嚼区进行重复电刺激可以引起有节奏的下颌运动（RJMs）；这已在灵长类动物 (1, 1 I-13, 17, 33)、猫 (2, 18, 20, 24, 25, 28)、兔子 (2, 14, 19, 27, 30, 32) 和豚鼠 (27) 中得到证实。 Rioch（27 岁）是最早记录此类皮质刺激引起的下颌运动的研究人员之一。她报告说，在兔子和豚鼠身上，列车中的每次刺激都会产生“精细类型的下颌运动”，以及开颌肌肉的“精细”或“小”收缩（27）。在 1 到 9 Hz 之间的皮层刺激频率下，这些精细收缩是观察到的唯一反应，但在 9 Hz 以上的频率下，很快就达到阈值（9 到 20 Hz 之间），此时会诱发以大约 2.5 Hz 的频率发生的 RJM (27)。还观察到，每次刺激引起的精细运动继续产生，但现在叠加在 RJM 期间发生的下颌的“大偏移”上。在高达 64 Hz 的皮质刺激率下观察到精细运动 (27)。在之前的研究中，我们已经证明了在麻醉豚鼠自发发生有节奏的下颌运动期间，在三叉神经运动神经元中进行细胞内记录的可行性 (7, 9)。在本研究中，我们使用这种准备来检查由每个皮质刺激引起的离散下颌运动的神经生理学机制，以及这些离散运动与由高于约 1 O-20 Hz 的皮质刺激序列引起的 RJM 的关系。其中一些数据的初步报告已在其他地方提出（10）。
The observation has been repeatedly made that repetitive, electrical stimulation of the face or masticatory area of the motor cortex of experimental animals can evoke rhythmical jaw movements (RJMs); this has been demonstrated in primates (1, 1 I-13, 17, 33), cat (2, 18, 20, 24, 25, 28), rabbits (2, 14, 19, 27, 30, 32), and guinea pigs (27). Rioch (27) was one of the first investigators to record jaw movements evoked by such cortical stimuli. She reported, in rabbits and guinea pigs, that each stimulus in the train produced a “fine type of jaw movement,” and “fine” or “small” contractions of the jaw-opener muscles (27). At cortical stimulus frequencies of between 1 and 9 Hz these fine contractions were the only responses observed, but at frequencies above 9 Hz one soon reached a threshold (between 9 and 20 Hz), at which point RJMs, occurring at a frequency of approximately 2.5 Hz, were induced (27). The observation was also made that the fine movements evoked by each stimulus continued to be produced but were now superimposed on “large excursions” of the jaw that occurred during the RJMs. The fine movements were observed at cortical stimulus rates as high as 64 Hz (27). In previous studies we have demonstrated the feasibility of recording intracellularly in trigeminal motoneurons in the anesthetized guinea pig during spontaneously occurring rhythmic jaw movements (7, 9). In the present study we have used this preparation to examine the neurophysiologic mechanisms underlying the discrete jaw movements evoked by each cortical stimulus and the relationship of these discrete movements to the RJMs induced by cortical stimulus trains above approximately 1 O-20 Hz. A preliminary report of some of these data was presented elsewhere (10).