A novel cholic acid-based contrast enhancement agent for targeted MRI.
A novel cholic acid-based contrast enhancement agent for targeted MRI.
复制标题
DOI：
10.1016/j.bmcl.2008.01.044
复制
发表时间：
2008-04
影响因子：
2.7
通讯作者：
Hyun-Soon Chong;Hyun A. Song;Sooyoun Lim;Keith W Macrenaris;Xiang Ma;Haisung Lee;P. Bui;T. Meade
中科院分区：
文献类型：
--
作者：
Hyun-Soon Chong;Hyun A. Song;Sooyoun Lim;Keith W Macrenaris;Xiang Ma;Haisung Lee;P. Bui;T. Meade
合成了七齿配体NE3TA和NE3TA-Bn的新型Gd(III)配合物，测量了它们的弛豫性能，并与市售的磁共振造影剂Gd(DOTA)进行了比较。NE3TA与胆酸(CA)偶联，得到CA-NE3TA。Gd(CA-NE3TA)的电子显微镜照片表明，该络合物自组装形成纳米胶束，并显示出比Gd(DOTA)高三倍以上的弛豫度。新型胆酸偶联纳米磁共振造影剂Gd(CA-NE3TA)在靶向磁共振成像中具有广阔的应用前景。
The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.