A METAANALYSIS OF ALCOHOLIC BEVERAGE CONSUMPTION IN RELATION TO RISK OF COLORECTAL-CANCER
A METAANALYSIS OF ALCOHOLIC BEVERAGE CONSUMPTION IN RELATION TO RISK OF COLORECTAL-CANCER
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DOI：
10.1007/bf00053184
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发表时间：
1990-07-01
影响因子：
2.3
通讯作者：
CHALMERS, TC
中科院分区：
文献类型：
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作者：
LONGNECKER, MP;ORZA, MJ;CHALMERS, TC
定量方法被用来审查流行病学数据有关的消费酒精饮料的风险，结直肠癌。 数据（27项研究）支持弱关联的存在。 对于每天饮用两种酒精饮料，结直肠癌的平均相对风险为1.10（95%置信区间为1.05 - 1.14）。 其他调查结果是：（1）这种关联并不因性别或大肠部位而异：（2）随访研究的结果（相对危险度1.32，95%可信区间1.16 - 1.51）表明与病例对照研究的结果有更强的关系（相对危险度1.07，95%置信区间1.02 - 1.12）;尽管结果与啤酒消费量有更强的关联，但支持饮料特异性的证据并不确凿（相对危险度1.26，95%可信区间1.13 - 1.41）比饮用葡萄酒（相对危险度1.11，95%可信区间0.91 - 1.36）或白酒（相对危险度1.13，95%可信区间0.99 - 1.29）更高。 由于饮酒与结直肠癌风险之间的关联程度很小，因此关于酒精因果作用的研究结果并不确定。
Quantitative methods were used to review epidemiologic data relating consumption of alcoholic beverages to risk of colorectal cancer. The data (27 studies) supported the presence of a weak association. For consumption of two alcoholic beverages daily, on average the relative risk of colorectal cancer was 1.10 (95% confidence interval 1.05 - 1.14). Other findings were: (1) the association did not vary according to gender or site within the large bowel: (2) results from follow-up studies (relative risk 1.32, 95% confidence interval 1.16 - 1.51) suggested a stronger relationship than those from case-control studies (relative risk 1.07, 95% confidence interval 1.02 - 1.12); and (3) the evidence supporting beverage specificity was not conclusive, although the results were consistent with a stronger association with consumption of beer (relative risk 1.26, 95% confidence interval 1.13 - 1.41) than with consumption of wine (relative risk 1.11, 95% confidence interval 0.91 - 1.36) or liquor (relative risk 1.13, 95% confidence interval 0.99 - 1.29). Because the magnitude of the association between alcohol consumption and risk of colorectal cancer was small, the findings regarding a causal role of alcohol were inconclusive.