Visceral Abdominal Obesity Is Associated With an Increased Risk of Irritable Bowel Syndrome
Visceral Abdominal Obesity Is Associated With an Increased Risk of Irritable Bowel Syndrome
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DOI：
10.1038/ajg.2014.422
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发表时间：
2015-02-01
影响因子：
9.8
通讯作者：
Kang, Hyoun Woo
中科院分区：
文献类型：
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作者：
Lee, Chang Geun;Lee, Jun Kyu;Kang, Hyoun Woo
目的：有几项研究认为肥胖是各种下胃肠道症状的危险因素。但内脏腹型肥胖与肠易激综合征(IBS)发病率之间的关系尚未得到研究。本研究旨在探讨内脏脂肪组织(VAT)与IBS发病风险的关系。方法：对2012年1月至2013年8月在某健康促进中心接受腹部CT检查的IBS患者(IBS组)和非IBS患者(非IBS组)的VAT面积进行病例对照研究。根据罗马III标准进行电话调查，以诊断IBS。通过测量VAT、皮下脂肪组织(SAT)、VAT/SAT比值、体重指数(BMI)和腰围(WC)来评价IBS与腹型肥胖的关系。结果：IBS患病率为19.9%(67/336)。单因素分析显示，IBS组VAT面积、VAT/SAT比值、腰围、反流性食管炎发生率及女性比例显著高于非IBS组。然而，较高的BMI或较高的SAT区域与IBS风险的增加无关。在多因素分析中，增值税面积(优势比OR=9.42，95%可信区间：2.9~30.64，最高三分位数与最低三分位数比较，P=0.001)、增值税/增值税比值(OR=10.15，95%可信区间：3.05~33.58，最高三分位数与最低三分位数比较，P=0.001)和腰围(OR=7.81，95%可信区间：2.13~28.66，最高三分位数与最低三分位数，P=0.002)是肠易激综合征的独立危险因素。只有在IBS-D组，而不是在IBS-C组，内脏肥胖与IBS风险增加相关。结论：内脏肥胖与IBS风险增加相关，尤其是IBS-D。然而，SAT和BMI都不会增加IBS的风险。
OBJECTIVES: There are several studies considering obesity as the risk factor for various lower gastrointestinal symptoms. But the relationship between visceral abdominal obesity and the incidence of irritable bowel syndrome (IBS) is not studied yet. The aim of this study was to investigate the association between visceral adipose tissue (VAT) and the risk of IBS.METHODS: This is a case-control study comparing the VAT area between subjects with IBS (IBS group) and controls without IBS (non IBS group), who underwent abdomen computerized tomography (CT) for routine health checkup from January 2012 to August 2013 in a health promotion center. A telephone survey was retrospectively conducted to diagnose IBS by Rome III criteria. The association between IBS and abdominal obesity was evaluated by measuring VAT, subcutaneous adipose tissue (SAT), VAT/SAT ratio, body mass index (BMI) and waist circumference (WC).RESULTS: The prevalence of IBS was 19.9% (67/336) among all enrolled subjects. In the univariate analysis, VAT area, VAT/SAT ratio, waist circumference, the presence of reflux esophagitis and the ratio of females were significantly higher in the IBS group than in the non IBS group. However, a higher BMI or a higher SAT area is not associated with an increased risk of IBS. In the multivariate analysis, a higher VAT area (odds ratio (OR) = 9.42, 95% confidence interval (CI): 2.90-30.64, highest tertile vs. lowest tertile, P = 0.001), VAT/SAT ratio (OR = 10.15, 95% CI: 3.05-33.58, highest tertile vs. lowest tertile, P = 0.001) and waist circumference (OR = 7.81, 95% CI: 2.13-28.66, highest tertile vs. lowest tertile, P = 0.002) were independently associated with a risk of IBS. Only in the IBS-D group, not in the IBS-C, visceral adiposity was associated with an increased risk of IBS.CONCLUSIONS: Visceral adiposity measured by VAT, VAT/SAT, and waist circumference is associated with an increased risk of IBS, especially of IBS-D. However, neither SAT nor BMI are associated with an increased risk of IBS.