CD4+ Lymphocyte Increases in HIV Patients during Potent Antiretroviral Therapy Are Dependent on Inhibition of CD8+ Cell Apoptosis
CD4+ Lymphocyte Increases in HIV Patients during Potent Antiretroviral Therapy Are Dependent on Inhibition of CD8+ Cell Apoptosis
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DOI：
10.1196/annals.1299.104
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发表时间：
2003-12
影响因子：
5.2
通讯作者：
S. Grelli;G. d’Ettore;F. Lauria;F. Montella;L. Traglia;C. D'Agostini;M. Lichtner;V. Vullo;C. Favalli;S. Vella;B. Macchi;A. Mastino
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文献类型：
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作者：
S. Grelli;G. d’Ettore;F. Lauria;F. Montella;L. Traglia;C. D'Agostini;M. Lichtner;V. Vullo;C. Favalli;S. Vella;B. Macchi;A. Mastino
摘要：尽管在强效抗逆转录病毒治疗期间抑制细胞凋亡有助于免疫重建，但其与治疗反应的主要指标（即CD4+细胞计数和病毒载量（VL）的变化）的关系仍有争议。我们扩展了我们以前的研究，通过收集关于细胞凋亡与免疫学和病毒学参数之间关系的数据，这些数据来自对强效抗逆转录病毒治疗总体呈阳性反应的HIV患者的长期随访。我们报告了15例完成两年治疗的患者的结果。在一个较小的患者组中，我们将注意力集中在研究CD8+亚群在淋巴细胞凋亡总体变化中的具体作用，这些变化伴随着对治疗的反应而发生。我们的数据，同时再次证实，PBMC凋亡的抑制是一种现象，严格相关的一个有效的抗逆转录病毒治疗的积极反应，表明CD4+细胞救援是不直接依赖于抑制CD4+细胞凋亡，而是对CD8+亚群。
Abstract: Although suppression of apoptosis contributes to immune‐reconstitution during potent antiretroviral therapy, its relationship with the majors indicators of response to therapy, that is, changes in CD4+ cell counts and in viral loads (VL), is still debated. We extended our previous study by collecting data on the relationships among apoptosis and immunological and virological parameters during a long‐term follow‐up of HIV patients with an overall positive response to potent antiretroviral therapy. We report results from 15 patients who completed two years of therapy. In a smaller group of patients, we focused our attention on investigating the specific contribution of the CD8+ subset in the overall changes in lymphocyte apoptosis, which occur concomitantly with the response to the therapy. Our data, while again confirming that inhibition of PBMC apoptosis is a phenomenon strictly related to a positive response to potent antiretroviral therapy, suggest that CD4+ cell rescue is not directly dependent on inhibition of CD4+ cell apoptosis but rather on that of the CD8+ subset.