Age and other factors in motor recovery from precentral lesions in monkeys
Age and other factors in motor recovery from precentral lesions in monkeys
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DOI：
10.1152/ajplegacy.1936.115.1.138
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发表时间：
1936-03-01
影响因子：
--
通讯作者：
Kennard, MA
中科院分区：
文献类型：
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作者：
Kennard, MA
在单侧和双侧皮质运动区和运动前区消融后，猴子四肢运动能力的恢复受到多种因素的影响。动物的年龄影响3恢复速度和运动缺陷程度，年轻和未成熟的动物比成年动物恢复得更快更广泛。单个半球损伤的大小也会影响恢复，损伤较小后恢复速度要快得多，尽管这些损伤可能包括给定肢体的所有可兴奋运动组织。四肢同侧半球也会影响恢复，因为从该侧运动区切除会导致额外的同侧缺陷。在老年动物中，当两个半球的运动前运动区域连续消融之间的间隔超过 4 周时，会有一定程度的恢复。这种随意运动的轻微恢复发生在首先瘫痪的一侧。在通常存在强迫抓握且运动性能仍不协调的情况下接受手术的幼猴中，去除一侧的前运动和运动区域对运动性能几乎没有影响；在这样的婴儿中，在第一次手术完全恢复后，第二半球运动区的切除会产生永久性缺陷，但随意运动可以充分进行，因此动物能够维持自身并正常生长和发育。这种动物在发育良好时（2岁）的运动表现与幼年猕猴相似。持续用力抓握，动作缓慢且不协调。
Recovery of motor power in the extremities of monkeys after unilateral and bilateral ablations of the motor and premotor areas of the cortex is influenced by a number of factors. The age of the animals affect3 both rate of recovery and degree of motor deficit young and immature animals recover more quickly and extensively than adults. The size of the lesion made in a single hemisphere also affects recovery, which is much more rapid after smaller lesions even though these may include all excitable motor tissue for a given extremity. The hemisphere ipsilateral to the extremities also influences recovery since extirpation from the motor areas of this side causes additional ipsilateral deficit. In older animals when the interval between successive ablations of the motor-premotor areas of the 2 hemispheres exceeds 4 weeks there is some recovery. This slight return of voluntary movement occurs on the side that was first paralyzed. In infant monkeys operated upon when forced grasping is normally present and when motor performance is still poorly coordinated, removal of the premotor and motor areas of one side has little effect on motor performance ; in such an infant extirpation of the motor areas of the 2d hemisphere after complete recovery from the first operation produces a permanent deficit, but voluntary movements are adequately performed, so that the animal is able to maintain itself, and to grow and develop normally. The motor performance of such an animal, when well-grown (2 yrs. of age) resembles that of the infant macaque. Forced grasping persists and movements are slow and incoordinated.