GONADAL-HORMONES INFLUENCE THE EMERGENCE OF CORTICAL FUNCTION IN NONHUMAN-PRIMATES
GONADAL-HORMONES INFLUENCE THE EMERGENCE OF CORTICAL FUNCTION IN NONHUMAN-PRIMATES
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DOI：
10.1037/0735-7044.103.6.1287
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发表时间：
1989-12-01
影响因子：
1.9
通讯作者：
GOLDMANRAKIC, PS
中科院分区：
文献类型：
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作者：
CLARK, AS;GOLDMANRAKIC, PS
在正常雄性和雌性恒河猴、50日龄眶前额叶损伤猴和不同日龄给予雄激素的雌猴中研究了性腺激素在眶前额叶皮质（ORB）成熟中的作用。猴子在75日龄时进行物体辨别反转任务测试。性别影响猴子在正常发育过程中和ORB病变后的任务表现。正常的男性比正常的女性犯的错误要少。雄激素处理的雌性表现与正常雄性猴相似。ORB病变产生赤字的雄性猴子和雌性动物给予雄激素在产前后期或出生后早期的生活，但在正常的女性。这些发现表明，性腺激素可能在非人灵长类动物的高级皮质功能分化中起诱导作用。
The role of gonadal hormones in the maturation of the orbital prefrontal cortex (ORB) was studied in normal male and female rhesus monkeys, monkeys given ORB lesions at 50 days of age, and female monkeys given androgen at different ages. Monkeys were tested on an object discrimination reversal task at 75 days of age. Gender influenced the performance of monkeys on the task during normal development and after ORB lesions. Normal males made fewer errors than did normal females. Females treated with androgen performed similarly to normal male monkeys. ORB lesions produced deficits in male monkeys and in females given androgen during late prenatal or early postnatal life, but not in normal females. These findings suggest that gonadal hormones may play an inductive role in the differentiation of higher cortical function in nonhuman primates.