MYC-MAX-MAD - A TRANSCRIPTION FACTOR NETWORK CONTROLLING CELL-CYCLE PROGRESSION, DIFFERENTIATION AND DEATH
MYC-MAX-MAD - A TRANSCRIPTION FACTOR NETWORK CONTROLLING CELL-CYCLE PROGRESSION, DIFFERENTIATION AND DEATH
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DOI：
10.1016/0959-437x(94)90098-1
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发表时间：
1994-02-01
影响因子：
4
通讯作者：
LAND, H
中科院分区：
文献类型：
--
作者：
AMATI, B;LAND, H
Myc癌蛋白与其配偶体Max二聚化，以结合DNA，激活转录，并促进细胞增殖以及程序性细胞死亡。Max还与其替代伙伴Mad和Mxi-1形成同源二聚体或异源二聚体。这些复合物通过竞争常见的DNA靶标而表现为Myc/Max的拮抗剂，并且可能允许细胞分化。
The Myc oncoprotein dimerizes with its partner, Max, to bind DNA, activate transcription, and promote cell proliferation, as well as programmed cell death. Max also forms homodimers or heterodimers with its alternative partners, Mad and Mxi-1. These complexes behave as antagonists of Myc/Max through competition for common DNA targets, and perhaps permit cellular differentiation.