MUTUAL INDEPENDENCE OF ENDOLYMPHATIC POTENTIAL AND CONCENTRATIONS OF SODIUM AND POTASSIUM IN ENDOLYMPH
MUTUAL INDEPENDENCE OF ENDOLYMPHATIC POTENTIAL AND CONCENTRATIONS OF SODIUM AND POTASSIUM IN ENDOLYMPH
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DOI：
10.1172/jci107442
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发表时间：
1973-01-01
影响因子：
15.9
通讯作者：
GORDES, E
中科院分区：
文献类型：
--
作者：
BRUSILOW, SW;GORDES, E
通过测量内淋巴中不同浓度的钠和钾的 EP 以及测量降低的 EP 对这些阳离子浓度的影响，研究了内淋巴电位 (EP) 与内淋巴和间质液之间的钠和钾浓度梯度之间的关系。在狗身上使用依他尼酸，将内淋巴中钠和钾的浓度（毫克当量/升）分别从 5.8 和 148 改变为 134 和 24.3。 EP 中没有伴随这些改变而发生变化。在第二组实验中，EP 从 + 72 mV 降低至 + 31 mV，平均持续时间为 20 分钟。 EP减少期间内淋巴中钠和钾的浓度没有变化。这些数据表明 EP 与内淋巴中钠和钾浓度之间几乎没有关系。
The relationship between the endolymphatic potential (EP) and the sodium and potassium concentration gradients between endolymph and interstitial fluid was studied both by measuring the EP at varying concentrations of sodium and potassium in endolymph and by measuring the effect of a depressed EP on the concentrations of these cations. Ethacrynic acid was used in dogs to change the concentration of sodium and potassium (meq/liter) in endolymph from 5.8 and 148 to 134 and 24.3, respectively. No change in the EP accompanied these alterations. In a second series of experiments the EP was reduced from + 72 mV to + 31 mV for a mean duration of 20 min. No change in the concentration of sodium and potassium in endolymph was found during the period of reduced EP. These data suggest that there is little relationship between the EP and the sodium and potassium concentrations in endolymph.