The renewal of rod and cone outer segments in the rhesus monkey.
The renewal of rod and cone outer segments in the rhesus monkey.
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DOI：
10.1083/jcb.49.2.303
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发表时间：
1971-05-01
期刊：
影响因子：
--
通讯作者：
Young RW
中科院分区：
文献类型：
--
作者：
Young RW
用放射自显影术研究了恒河猴视网膜视杆细胞和视锥细胞外段的更新。细胞外节由一堆感光膜盘组成。在视杆细胞和视锥细胞中，一些新形成的（放射性）蛋白质分布在整个外节。此外，在杆（但不是在锥），有一个横向带浓缩放射性蛋白略高于外节基部注射后2天。这是由于新圆盘的形成，标记的蛋白质已掺入其中。在第4天，这些放射性盘位于远离外节基底。新椎间盘的重复组装使其远离基底组装部位并沿沿着移位。位移率的测量表明，每个视网膜杆每天产生80-90个盘，并且每9-13天更换一次整个外节盘。为了弥补新的光盘的持续形成，旧光盘组间歇地从细胞的顶端脱落，并被色素上皮吞噬。每个色素上皮细胞吞噬和破坏约2000-4000杆外节光盘每天。恒河猴和人类视觉细胞的相似性表明，人类视网膜也有同样的更新过程。
The renewal of retinal rod and cone outer segments has been studied by radioautography in rhesus monkeys examined 2 and 4 days after injection of leucine-3H. The cell outer segment consists of a stack of photosensitive, membranous discs. In both rods and cones some of the newly formed (radioactive) protein became distributed throughout the outer segment. Furthermore, in rods (but not in cones), there was a transverse band of concentrated radioactive protein slightly above the outer segment base 2 days after injection. This was due to the formation of new discs, into which labeled protein had been incorporated. At 4 days, these radioactive discs were located farther from the outer segment base. Repeated assembly of new discs had displaced them away from the basal assembly site and along the outer segment. Measurements of the displacement rate indicated that each retinal rod produces 80–90 discs per day, and that the entire complement of outer segment discs is replaced every 9–13 days. To compensate for the continual formation of new discs, groups of old discs are intermittently shed from the apical end of the cell and phagocytized by the pigment epithelium. Each pigment epithelial cell engulfs and destroys about 2000–4000 rod outer segment discs daily. The similarity between visual cells in the rhesus monkey and those in man suggests that the same renewal processes occur in the human retina.