Extensive conservation of the proneuropeptide and peptide prohormone complement in mollusks
Extensive conservation of the proneuropeptide and peptide prohormone complement in mollusks
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DOI：
10.1038/s41598-019-40949-0
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发表时间：
2019-03-19
影响因子：
4.6
通讯作者：
Wanninger, A.
中科院分区：
文献类型：
--
作者：
De Oliveira, A. L.;Calcina, A.;Wanninger, A.
作为最多样化的无脊椎动物群体之一，软体动物代表了神经生物学和发育研究的强大模型。神经肽和肽激素是一类异质信号分子，参与神经元之间的化学通讯和神经内分泌调节。在这里，我们展示了软体动物神经肽和肽激素工具包的细粒度视图。我们的结果扩大了轮轮动物中几个肽家族（例如动力蛋白原、胰岛素相关肽、激素原-4、LFRFamide）的分布，并为其他肽家族（例如 GNXQN/激素原-2、神经蛋白）的早期起源提供了证据。我们发现了一个广泛分布于贝壳类软体动物中的新肽家族，即 PXRX 家族。我们在轮轮动物和线虫中发现了 Wnt 拮抗剂 dickkopf1/2/4 直向同源物，并揭示了产卵激素家族是仅限于腹足动物的 DH44 同源物。我们的数据表明，许多肽的进化比以前假设的要早得多，并且关键信号元件在现存软体动物中广泛保守。
As one of the most diverse groups of invertebrate animals, mollusks represent powerful models for neurobiological and developmental studies. Neuropeptides and peptide hormones are a heterogeneous class of signalling molecules involved in chemical communication between neurons and in neuroendocrine regulation. Here we present a fine-grained view of the molluscan neuropeptide and peptide hormone toolkit. Our results expand the distribution of several peptide families (e.g., prokineticin, insulin-related peptides, prohormone-4, LFRFamide) within Lophotrochozoa and provide evidence for an early origin of others (e.g., GNXQN/prohormone-2, neuroparsin). We identified a new peptide family broadly distributed among conchiferan mollusks, the PXRX family. We found the Wnt antagonist dickkopf1/2/4 ortholog in lophotrochozoans and nematodes and reveal that the egg-laying hormone family is a DH44 homolog restricted to gastropods. Our data demonstrate that numerous peptides evolved much earlier than previously assumed and that key signalling elements are extensively conserved among extant mollusks.