Immune response to meningococcal serogroup C conjugate vaccine in asplenic individuals
Immune response to meningococcal serogroup C conjugate vaccine in asplenic individuals
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DOI：
10.1128/iai.72.1.332-337.2004
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发表时间：
2004-01-01
影响因子：
3.1
通讯作者：
Borrow, R
中科院分区：
文献类型：
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作者：
Balmer, P;Falconer, M;Borrow, R
已知无脾个体感染有荚膜细菌的风险增加。英国最近的建议指出，这一高危人群应接种一剂 C 群脑膜炎球菌结合疫苗 (MCC)。然而，无脾个体对 MCC 疫苗的免疫反应尚不清楚。研究了无脾动物 (n = 130) 对 MCC 疫苗免疫的免疫反应。无脾个体血清中杀菌抗体（SBA）的几何平均滴度（GMT）（157.8；95%置信区间[CI]，94.5至263.3）显着低于年龄匹配的对照组（n = 48）（1448.2；95% CI，751.1至2792.0）。然而，80% 的无脾个体达到了建议的保护性 SBA 滴度大于或等于 8。两组之间血清群 C 特异性免疫球蛋白 G 几何平均浓度没有观察到差异。如果脾切除的原因是医疗原因或如果进行了 MCC 疫苗接种，则观察到 SBA GMT 或达到 SBA 滴度大于或等于 8 的应答者数量显着减少
Asplenic individuals are known to be at increased risk of infection with encapsulated bacteria. Recent United Kingdom recommendations stated that this at-risk group should receive one dose of the meningococcal serogroup C conjugate (MCC) vaccine. However, the immune response of asplenic individuals to MCC vaccine is unknown. The immune response of asplenics (n = 130) to immunization with the MCC vaccine was investigated. Asplenic individuals had a significantly lower geometric mean titer (GMT) (157.8; 95% confidence interval [CI], 94.5 to 263.3) of bactericidal antibody in serum (SBA) than an age-matched control group (n = 48) (1448.2; 95% CI, 751.1 to 2792.0). However, 80% of asplenic individuals achieved the proposed protective SBA titer of greater than or equal to8. No differences were observed between the two groups in the serogroup C-specific immunoglobulin G geometric mean concentration. A significant reduction in SBA GMT or the number of responders achieving an SBA titer of greater than or equal to8 was observed if the reason for splenectomy was a medical cause or if MCC vaccination occurred