An investigation of female adolescent twins with both major depression and conduct disorder
An investigation of female adolescent twins with both major depression and conduct disorder
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DOI：
10.1097/00004583-200103000-00009
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发表时间：
2001-03-01
影响因子：
13.3
通讯作者：
Iacono, WG
中科院分区：
文献类型：
--
作者：
Marmorstein, NR;Iacono, WG
目的：行为障碍（CD）和抑郁症（MDD）经常同时发生在青少年中，但对患有这两种疾病的青少年，特别是女性的特征和功能知之甚少。这项研究描述了功能的女性青少年与历史的CD和MDD。方法：受试者选自流行病学样本的17岁的女性双胞胎的基础上有一个终身的DSM-III-R诊断的MDD和/或CD;对照组受试者没有任何疾病的历史。结果如下：在几乎所有的领域检查，包括学业成功的措施（包括学业成绩和学校的调整），个性，同伴关系的质量，和高风险的行为（包括物质依赖和早期性经验），一个或两个障碍的主要影响被发现，并与受损的功能。此外，在物质依赖症状（对于所有种类的物质），负面的学校相关事件和基于个性的倾向不经历积极的情绪等领域发现了相互作用效应，这表明那些同时患有这两种诊断的人特别受损。结论：在某些领域，MDD和CD的历史相互作用，并与特别严重的问题有关。这些研究结果的影响远的研究和治疗，包括物质和学校的适应问题，在这些年轻人的高可能性，进行了讨论。
Objective: Conduct disorder (CD) and major depression (MDD) frequently co-occur in adolescents, but little is known about the characteristics and functioning of youths, especially females, with both disorders. This study describes the functioning of female adolescents with histories of both CD and MDD. Method: Subjects were selected from an epidemiological sample of 17-year-old female twins based on having a lifetime DSM-III-R diagnosis of MDD and/or CD; control subjects had no history of either disorder. Results: In nearly all domains examined, including measures of academic success (including academic achievement and school adjustment), personality, quality of peer relationships, and high-risk behavior (including substance dependence and early sexual experience), main effects of one or both disorders were found and related to impaired functioning. In addition, interaction effects were found in the areas of substance dependence symptoms (for all classes of substances), negative school-related events, and a personality-based predisposition not to experience positive emotions, indicating that those with both diagnoses were especially impaired. Conclusions: In some domains, histories of MDD and CD interact and relate to particularly severe problems. The implications of these findings far research and treatment, including the high likelihood of substance and school adjustment problems in these youths, are discussed.