Anterior cingulate activity correlates with blood pressure during stress
Anterior cingulate activity correlates with blood pressure during stress
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DOI：
10.1111/j.1469-8986.2005.00366.x
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发表时间：
2005-11-01
期刊：
影响因子：
3.7
通讯作者：
Jennings, JR
中科院分区：
文献类型：
--
作者：
Gianaros, PJ;Derbyshire, SWG;Jennings, JR
据推测，前扣带皮层调节血压对行为压力源的反应。然而，在人类中，几乎没有证据表明压力源引起的血压变化与前扣带回活动的同时变化相关。使用功能磁共振成像，我们测试了 9 名女性和 11 名男性完成了紧张的斯特鲁普色词干扰任务后，平均动脉血压的变化是否与血氧水平依赖性 (BOLD) 激活的持续变化相关。 Stroop 任务期间较高的平均动脉压与扣带皮层两个区域（膝周和中前部）以及其他网络化大脑区域（包括岛叶、丘脑和导水管周围灰质）的 BOLD 激活程度较高相关。这些结果支持这样的假设：前扣带皮层调节人类对行为压力源的血压反应。
The anterior cingulate cortex presumptively regulates blood pressure reactions to behavioral stressors. There is little evidence in humans, however, that stressor-evoked changes in blood pressure correlate with concurrent changes in anterior cingulate activity. Using fMRI, we tested whether changes in mean arterial blood pressure correlate with ongoing changes in blood oxygen level dependent (BOLD) activation in 9 women and 11 men who completed a stressful Stroop color-word interference task. Higher mean arterial pressure during the Stroop task correlated with greater BOLD activation in two regions of the cingulate cortex (perigenual and mid-anterior) and in other networked brain regions, including the insula, thalamus, and periaqueductal gray. These results support the hypothesis that the anterior cingulate cortex regulates blood pressure reactions to behavioral stressors in humans.