Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns
复制标题
DOI：
10.1097/aog.0000000000004199
复制
发表时间：
2021-01-01
影响因子：
7.2
通讯作者：
Nielsen, Henriette Svarre
中科院分区：
文献类型：
--
作者：
Egerup, Pia;Fich Olsen, Line;Nielsen, Henriette Svarre
目的：调查严重急性呼吸综合征冠状病毒2型的频率（SARS-CoV-2）抗体在临产妇女、其伴侣和新生儿中的作用，以及这些抗体与产科和新生儿结局的关系。2020年4月4日至7月3日，在丹麦的一所大学医院，所有临产妇女及其伴侣都被邀请参加研究，沿着他们的新生儿。参与的妇女和伴侣在入院时采集咽拭子和血液样本;分娩后立即从脐带中抽取血液样本。通过聚合酶链反应分析拭子中的SARS-CoV-2 RNA，并分析血液样本中的SARS-CoV-2抗体。结果：1，313例产妇（72.5%）中，有1例为新生儿，有1例为新生儿在研究期间，所有住院分娩的妇女中有1，188名伴侣和1，206名新生儿参加了这项研究。调整后的血清学患病率在女性中为2.6%，在伴侣中为3.5%。17名新生儿有SARS-CoV-2免疫球蛋白G（IgG）抗体，无免疫球蛋白M抗体。未发现SARS-CoV-2抗体与产科或新生儿并发症（如早产、先兆子痫、剖宫产、Apgar评分、低出生体重、脐动脉pH值、需要持续气道正压通气或新生儿入院）之间存在关联，但检测此类差异的统计学把握度较低。来自1,051个家庭的完整血清学数据显示，如果伴侣有抗体，母亲感染的绝对风险为39%。结论：我们发现SARS-CoV-2感染与产科或新生儿并发症之间没有关联。在有抗体的母亲所生的新生儿中，67%有SARS-CoV-2 IgG抗体。我们的研究的一个局限性是，我们缺乏统计能力来检测那些有感染证据和没有感染证据的人之间微小但可能有意义的差异。
OBJECTIVE: To investigate the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in parturient women, their partners, and their newborns and the association of such antibodies with obstetric and neonatal outcomes.METHODS: From April 4 to July 3, 2020, in a single university hospital in Denmark, all parturient women and their partners were invited to participate in the study, along with their newborns. Participating women and partners had a pharyngeal swab and a blood sample taken at admission; immediately after delivery, a blood sample was drawn from the umbilical cord. The swabs were analyzed for SARS-CoV-2 RNA by polymerase chain reaction, and the blood samples were analyzed for SARS-CoV-2 antibodies. Full medical history and obstetric and neonatal information were available.RESULTS: A total of 1,313 parturient women (72.5.% of all women admitted for delivery at the hospital in the study period), 1,188 partners, and 1,206 newborns participated in the study. The adjusted serologic prevalence was 2.6% in women and 3.5% in partners. Seventeen newborns had SARS-CoV-2 immunoglobulin G (IgG) antibodies, and none had immunoglobulin M antibodies. No associations between SARS-CoV-2 antibodies and obstetric or neonatal complications were found (eg, preterm birth, preeclampsia, cesarean delivery, Apgar score, low birth weight, umbilical arterial pH, need for continuous positive airway pressure, or neonatal admission), but statistical power to detect such differences was low. Full serologic data from 1,051 families showed an absolute risk of maternal infection of 39% if the partner had antibodies.CONCLUSION: We found no association between SARS-CoV-2 infection and obstetric or neonatal complications. Sixty-seven percent of newborns delivered by mothers with antibodies had SARS-CoV-2 IgG antibodies. A limitation of our study is that we lacked statistical power to detect small but potentially meaningful differences between those with and without evidence of infection.