Noninvasive determination of liver collagen content in chronic hepatitis. Multivariate regression modeling with blood chemical parameters as variables
Noninvasive determination of liver collagen content in chronic hepatitis. Multivariate regression modeling with blood chemical parameters as variables
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DOI：
10.1007/bf02934493
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发表时间：
1997-06-01
影响因子：
6.3
通讯作者：
Nakano, H
中科院分区：
文献类型：
--
作者：
Takamatsu, S;Nakabayashi, H;Nakano, H
为评价血液生化指标对肝纤维化的诊断价值，检测了54例慢性病毒性肝病患者血清中Ⅲ型前胶原肽（P Ⅲ P）、Ⅳ型胶原（IV-collagen）、Ⅳ型胶原7S结构域（7S-collagen）和透明质酸（HA）水平。通过计算机辅助图像分析方法定量肝脏胶原蛋白含量。肝内胶原含量与血清P Ⅲ P（r = 0.482; P < 0.02）、IV型胶原（r = 0.705;P < 0.001）、7S型胶原（r = 0.771; P < 0.001）和HA（r = 0.595; P < 0.001）水平呈显著相关。为了优化诊断效果，我们将多变量回归分析应用于这些血液生化参数和一些额外的实验室检查的综合结果。应用该模型得到的相关系数为0.809。为了测量所提出的模型的预测价值，我们用它来估计另外16名慢性肝病患者的胶原蛋白含量，并将估计值与通过直接测量确定的实际胶原蛋白量进行比较。相关系数为0.937。这些结果表明，该模型的应用将是有用的纤维化肝胶原含量的评估。
To evaluate the diagnostic utility of blood biochemical parameters in assessing degree of hepatic fibrosis, serum levels of aminoterminal type III procollagen peptide (P III P), type IV collagen (IV-collagen), 7S domain of type IV collagen (7S-collagen), and hyaluronan (HA) were measured in 54 patients with chronic viral liver disease. Liver collagen content was quantified by a computer-assisted image analysis method. Significant correlations were found between the amount of collagen in the liver and serum levels of P III P (r = 0.482; P < 0.02), IV-collagen (r = 0.705;P < 0.001), 7S-collagen (r = 0.771; P < 0.001), and HA (r = 0.595; P < 0.001). To optimize diagnostic efficacy, we applied multivariate regression analysis to the combined results obtained for these blood biochemical parameters and some additional laboratory tests. The correlation coefficient obtained from the application of this model was 0.809. To measure the predictive value of the proposed model, we used it to estimate collagen content in an additional 16 patients with chronic liver disease and compared the estimated to the actual amount of collagen determined by direct measurement. The correlation coefficient was 0.937. These results suggest that application of the model would be useful for the assessment of collagen content of fibrotic liver.