Chitosan/cashew gum nanogels for essential oil encapsulation
Chitosan/cashew gum nanogels for essential oil encapsulation
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DOI：
10.1016/j.carbpol.2012.04.048
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发表时间：
2012-08-01
影响因子：
11.2
通讯作者：
de Paula, Regina C. M.
中科院分区：
文献类型：
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作者：
Abreu, Flavia O. M. S.;Oliveira, Erick F.;de Paula, Regina C. M.
制备了以壳聚糖和腰果胶为基质的纳米凝胶，并负载了油橄榄油。几个参数，如腰果胶浓度和相对油含量在基质中有他们的影响纳米凝胶性能的调查。对纳米凝胶的形貌、粒径分布、Zeta电位、傅里叶变换红外光谱和精油含量进行了表征。通过紫外/维斯光谱法研究释放曲线，并通过生物测定确定其功效。结果表明，以基质：油10：2、胶：壳聚糖1：1、胶浓度为5%的相对比例设计的样品，载药量为11.8%，包封率为70%。发现纳米凝胶表现出在335-558 nm范围内的平均尺寸。体外释药曲线显示纳米粒呈缓慢、持续释放。生物测定表明，幼虫死亡率主要与含油量有关，样品比纯L.西杜香油(C)2012爱思唯尔有限公司保留所有权利。
Nanogels based on chitosan and cashew gum were prepared and loaded with Lippia sidoides oil. Several parameters such as cashew gum concentration and relative oil content in the matrix had their influence on nanogel properties investigated. Nanogels were characterized regarding their morphologies, particle size distributions, zeta potential, Fourier transform infrared spectroscopy and essential oil contents. The release profile was investigated by UV/vis spectroscopy and its efficacy was determined through bioassays. Results showed that samples designed using relative ratios matrix:oil 10:2, gum:chitosan 1:1 and 5% gum concentration showed high loading (11.8%) and encapsulation efficiency (70%). Nanogels were found to exhibit average sizes in the range 335-558 nm. In vitro release profiles showed that nanoparticles presented slower and sustained release. Bioassays showed that larval mortality was related mainly to oil loading, with samples presenting more effective larvicide efficacies than the pure L. sidoides oil. (C) 2012 Elsevier Ltd. All rights reserved.