Elevated plasma endothelin-1 is associated with reduced weight loss post vertical sleeve gastrectomy
Elevated plasma endothelin-1 is associated with reduced weight loss post vertical sleeve gastrectomy
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DOI：
10.1016/j.soard.2019.03.047
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发表时间：
2019-07-01
影响因子：
3.1
通讯作者：
Speed, Joshua S.
中科院分区：
文献类型：
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作者：
Jenkins, Haley N.;Williams, London J.;Speed, Joshua S.
背景：肥胖和胰岛素抵抗与血浆内皮素-1（ET-1）水平呈正相关；然而，导致 ET-1 增加的机制尚不清楚。同样，ET-1 的完整生理复杂性仍有待描述，尤其是在肥胖中。迄今为止，治疗病态肥胖的最佳治疗方法之一是减肥手术，以快速减少体内脂肪和与肥胖相关疾病相关的因素；然而，尚未描述垂直袖状胃切除术 (SG) 对血浆 ET-1 的影响。目的：确定 SG 是否会降低血浆 ET-1 水平，并确定血浆 ET-1 浓度是否与手术后体重减轻相关。地点：研究在大学医院进行。方法：通过测量 SG 前后 12 名肥胖患者的血浆 ET-1 水平进行测试。所有数据均来自 SG 前、SG 后 6 周和术后 6 个月的临床就诊。结果：SG 后 6 周，血浆 ET-1 水平增加 24%；然而，6个月后，与术前相比下降了27%。 6 周后，该队列的平均体重减轻为 11.3% +/- 2.4% 体重，6 个月后平均体重减轻 21.4% +/- 5.7%。有趣的是，我们观察到基线血浆 ET-1 与体重减轻百分比 (R-2 = .49，P = .01) 以及减肥手术后 6 个月体重指数变化 (R-2 = .45，P = .011) 之间存在反比关系。结论：我们的结果表明 SG 降低血浆 ET-1 水平，这是改善这些患者代谢风险的可能机制。这些数据还表明 ET-1 可以作为减肥手术后体重减轻的预测因子。 (C) 2019 年由爱思唯尔公司代表美国减肥外科学会出版。
Background: Obesity and insulin resistance are positively correlated with plasma endothelin-1 (ET-1) levels; however, the mechanisms leading to increased ET-1 are not understood. Similarly, the full physiological complexity of ET-1 has yet to be described, especially in obesity. To date, one of the best treatments available for morbid obesity is bariatric surgery to quickly reduce body fat and the factors associated with obesity-related disease; however, the effects of vertical sleeve gastrectomy (SG) on plasma ET-1 have not been described.Objectives: To determine if SG will reduce plasma ET-1 levels and to determine if plasma ET-1 concentration is associated with weight loss after surgery.Setting: The studies were undertaken at a University Hospital.Methods: This was tested by measuring plasma ET-1 levels from 12 obese patients before and after SG. All data were collected from clinic visits before SG, 6 weeks after SG, and 6 months after surgery.Results: At 6 weeks after SG, plasma ET-1 levels increased by 24%; however, after 6 months, there was a 27% decrease compared with presurgery. Average weight loss in this cohort was 11.3% +/- 2.4% body weight after 6 weeks and 21.4% +/- 5.7% body weight after 6 months. Interestingly, we observed an inverse relationship between baseline plasma ET-1 and percent body weight loss (R-2 = .49, P = .01) and change in body mass index 6 months (R-2 = .45, P = .011) post bariatric surgery.Conclusions: Our results indicate that SG reduces plasma ET-1 levels, a possible mechanism for improved metabolic risk in these patients. These data also suggest that ET-1 may serve as a predictor of weight loss after bariatric surgery. (C) 2019 Published by Elsevier Inc. on behalf of American Society for Bariatric Surgery.