Defective utilization of haem in selenium-deficient rat liver.
Defective utilization of haem in selenium-deficient rat liver.
复制标题
缺硒大鼠肝脏中血红素的利用有缺陷。
DOI：
10.1042/bj2140053
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Burk,RF
中科院分区：
文献类型：
--
作者：
Correia,MA;Burk,RF
我们以前曾提出，一个固有的缺陷，在肝血红素利用是负责快速刺激肝微粒体血红素加氧酶活性观察到缺硒大鼠给予苯巴比妥，一个众所周知的血红素形成诱导剂。为了验证这一假设，故意提高肝血红素含量在硒缺乏大鼠的色氨酸或烯丙基异丙基乙酰胺，或通过注射血红素本身。我们现在报告说，与正常对照组相比，缺硒大鼠利用肝脏血红素的效率明显相对较低。因此，本文中详细的研究结果表明，肝微粒体血红素加氧酶活性的刺激确实是一种表现异常血红素利用硒缺乏。这表明硒在肝血红素代谢中的新作用。
We have previously suggested that an inherent defect in hepatic haem utilization was responsible for the rapid stimulation of hepatic microsomal haem oxygenase activity observed in selenium-deficient rats given phenobarbital, a well known inducer of haem formation. To test this hypothesis, hepatic haem content was deliberately raised in selenium-deficient rats by administration of either tryptophan or allylisopropylacetamide, or by injecting haem itself. We now report that selenium-deficient rats are apparently relatively less efficient in utilizing hepatic haem than normal controls. The findings detailed in the present paper thus indicate that stimulation of hepatic microsomal haem oxygenase activity is indeed a manifestation of abnormal haem utilization in selenium deficiency. This suggests a novel role for selenium in hepatic haem metabolism.