Regulation of angiotensin type 2 receptor in bovine granulosa cells.
Regulation of angiotensin type 2 receptor in bovine granulosa cells.
复制标题
牛颗粒细胞中血管紧张素2型受体的调节。
DOI：
10.1210/en.2007-1767
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发表时间：
2008
期刊：
影响因子：
4.8
通讯作者：
C. Price
中科院分区：
文献类型：
--
作者：
V. Portela;P. Gonçalves;A. Veiga;E. Nicola;J. Buratini;C. Price
Angiotensin II (AngII) is best known for its role in blood pressure regulation, but it also has documented actions in the reproductive system. There are two AngII receptors, type 1 (AGTR1) and type 2 (AGTR2). AGTR2 mediates the noncardiovascular effects of AngII and is expressed in the granulosa cell layer in rodents and is associated with follicle atresia. In contrast, expression of AGTR2 is reported to occur only in theca cells in cattle. The objective of the present study was to determine whether AngII also plays a role in follicle atresia in cattle. RT-PCR demonstrated AGTR2 mRNA in both granulosa and theca cells of bovine follicles. The presence of AGTR2 protein was confirmed by immunofluorescence. Abundance of AGTR2 mRNA in granulosa cells was higher in healthy compared with atretic follicles, whereas in theca cells, it did not change. Granulosa cells were cultured in serum-free medium, and treatment with hormones that increase estradiol secretion (FSH, IGF-I, and bone morphogenetic protein-7) increased AGTR2 mRNA and protein levels, whereas fibroblast growth factors inhibited estradiol secretion and AGTR2 protein levels. The addition of AngII or an AGTR2-specific agonist to granulosa cells in culture did not affect estradiol secretion or cell proliferation but inhibited abundance of mRNA encoding serine protease inhibitor E2, a protein involved in tissue remodeling. Because estradiol secretion is a major marker of nonatretic granulosa cells, these data suggest that AngII is not associated with follicle atresia in cattle but may have other specific roles during follicle growth.
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A23187 或血管紧张素 II 对大鼠卵巢金属蛋白酶抑制剂和类固醇生成的影响。
DOI：
10.1530/jrf.0.1110071
发表时间：
1997
期刊：
Journal of reproduction and fertility
影响因子：
--
作者：
Cannon,CM;Keeble,SC;CurryJr,TE
通讯作者：
CurryJr,TE
卵巢颗粒细胞 2 型血管紧张素 II 受体的生化特性。
影响因子：
4.8
作者：
Pucell,AG;Hodges,JC;Sen,I;Bumpus,FM;Husain,A
通讯作者：
Husain,A
妊娠和卵巢类固醇对绵羊子宫动脉内皮和血管平滑肌中血管紧张素 II 1 型和 2 型受体表达的调节。
DOI：
10.1080/10623320590933752
发表时间：
2005
期刊：
Endothelium : journal of endothelial cell research
影响因子：
--
作者：
Sullivan,JeremyA;Rupnow,HeidiL;Cale,JacquelineM;Magness,RonaldR;Bird,IanM
通讯作者：
Bird,IanM
影响因子：
56.9
作者：
PELLICER, A;PALUMBO, A;NAFTOLIN, F
通讯作者：
NAFTOLIN, F
大鼠卵巢闭锁卵泡上血管紧张素 II 受体选择性表达的证据：放射自显影研究。
影响因子：
4.8
作者：
Daud,AI;Bumpus,FM;Husain,A
通讯作者：
Husain,A