Sox genes and cancer
Sox genes and cancer
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DOI：
10.1159/000078217
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发表时间：
2004-01-01
影响因子：
1.7
通讯作者：
Koopman, P
中科院分区：
文献类型：
--
作者：
Dong, C;Wilhelm, D;Koopman, P
SOX基因编码属于HMG(High Mobility Group)超家族的转录因子。它们在物种间是保守的，并参与了许多发育过程。体外研究表明，至少有一个SOX基因能够诱导成纤维细胞的致癌转化。此外，SOX基因的过度表达和/或扩增与体内大量的肿瘤类型有关。我们在这里回顾了SOX基因表达与癌症相关的现有证据，并表明这种联系得到了广泛的EST数据库分析的支持。这项工作为进一步研究SOX基因在肿瘤发生过程中的可能作用提供了基础。版权所有(C)2004 S.Karger AG，巴塞尔。
Sox genes encode transcription factors belonging to the HMG ( High Mobility Group) superfamily. They are conserved across species and involved in a number of developmental processes. In vitro studies have shown at least one Sox gene to be capable of inducing oncogenic transformation of fibroblast cells. In addition, overexpression and/or amplification of Sox genes are associated with a large number of tumour types in vivo. We review here the available evidence linking Sox gene expression and cancer, and show that this link is supported by extensive EST database analysis. This work provides a basis for further studies aimed at investigating the possible role of Sox genes in the oncogenic process. Copyright (C) 2004 S. Karger AG, Basel.