Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation.
Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation.
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DOI：
10.1186/1478-811x-11-12
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发表时间：
2013-02-17
期刊：
影响因子：
--
通讯作者：
Ulrich H
中科院分区：
文献类型：
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作者：
Glaser T;Resende RR;Ulrich H
嘌呤能受体在几乎所有细胞类型中参与控制代谢活动和许多生理功能，包括信号传递、增殖和分化。虽然大多数P2Y受体通过激活细胞内钙池诱导细胞内钙浓度的瞬时升高，并将这些信号作为波转发，这些波也可以传递到邻近细胞中，但P2X受体产生钙峰，其也包括电压操作钙通道的激活。P2Y和P2X受体诱导钙瞬变，所述钙瞬变通过包括钙调蛋白和钙调神经磷酸酶的介质激活负责分化进程的转录因子。P2X2和P2X7受体的表达分别在分化的神经元和神经胶质细胞中增加。基因表达沉默试验表明，这些受体是重要的分化和神经元或胶质细胞的命运决定的进展。代谢型受体，主要是P2Y1和P2Y2亚型，通过诱导增殖以及通过NFAT易位调节神经分化作用于胚胎细胞或神经祖细胞阶段的细胞。本文就嘌呤能受体诱导的钙峰和钙波活动及其编码在神经发育和神经分化过程中的作用作一综述。
Purinergic receptors participate, in almost every cell type, in controlling metabolic activities and many physiological functions including signal transmission, proliferation and differentiation. While most of P2Y receptors induce transient elevations of intracellular calcium concentration by activation of intracellular calcium pools and forward these signals as waves which can also be transmitted into neighboring cells, P2X receptors produce calcium spikes which also include activation of voltage-operating calcium channels. P2Y and P2X receptors induce calcium transients that activate transcription factors responsible for the progress of differentiation through mediators including calmodulin and calcineurin. Expression of P2X2 as well as of P2X7 receptors increases in differentiating neurons and glial cells, respectively. Gene expression silencing assays indicate that these receptors are important for the progress of differentiation and neuronal or glial fate determination. Metabotropic receptors, mostly P2Y1 and P2Y2 subtypes, act on embryonic cells or cells at the neural progenitor stage by inducing proliferation as well as by regulation of neural differentiation through NFAT translocation. The scope of this review is to discuss the roles of purinergic receptor-induced calcium spike and wave activity and its codification in neurodevelopmental and neurodifferentiation processes.