Collimated superfine x-ray beam based x-ray luminescence computed tomography.
Collimated superfine x-ray beam based x-ray luminescence computed tomography.
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DOI：
10.3233/xst-17265
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发表时间：
2017
影响因子：
3
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Zhang W;Zhu D;Lun M;Li C
X射线发光计算机断层扫描（XLCT）是一种混合成像模式，具有实现高达数百微米的空间分辨率的潜力，目标嵌入混浊介质中的深度大于几毫米。本文报道了一种利用准直超细X射线束对深埋靶进行高空间分辨率XLCT成像的系统。一个准直器与100微米针孔安装在一个强大的X射线管的前面，以产生一个超细的X射线笔形光束，光束直径为0.175毫米。对于四个毛细血管的目标与边缘到边缘的距离为400微米的幻影实验，我们能够成功地重建的目标，在5毫米的深度，这与microCT图像进行了验证。我们进一步研究了不同的X射线束直径对重建XLCT图像的影响与数值模拟。我们的研究结果表明，XLCT有能力成功地成像多个深埋的目标时，准直的X射线束直径小于或等于目标的边缘到边缘的距离。我们的数值模拟还表明，如果扫描光束的直径为100微米，则XLCT对于嵌入深度为5 mm的目标可以实现200微米的空间分辨率。
X-ray luminescence computed tomography (XLCT) is a hybrid imaging modality with the potential to achieve a spatial resolution up to several hundred micrometers for targets embedded in turbid media with a depth larger than several millimeters. In this paper, we report a high spatial resolution XLCT imaging system with a collimated superfine x-ray beam in imaging the deeply embedded targets. A collimator with a 100 micrometer pinhole was mounted in the front of a powerful x-ray tube to generate a superfine x-ray pencil beam with a beam diameter of 0.175 mm. For the phantom experiment of four capillary targets with an edge-to-edge distance of 400 micrometers, we were able to reconstruct the targets in a depth of 5 mm successfully, which were validated with microCT images. We have further investigated the effect of different x-ray beam diameters on the reconstructed XLCT images with numerical simulations. Our results indicate that XLCT has the ability to image successfully multiple deeply embedded targets when the collimated x-ray beam diameter is less than or equal to the target edge-to-edge distance. Our numerical simulations also demonstrate that XLCT can achieve a spatial resolution of 200 micrometers for targets embedded at a depth of 5 mm if the scanning beam has a diameter of 100 micrometers.