24-h monitoring of plasma norepinephrine, MHPG, cortisol, growth hormone and prolactin in depression
24-h monitoring of plasma norepinephrine, MHPG, cortisol, growth hormone and prolactin in depression
复制标题
DOI：
10.1016/j.jpsychires.2004.03.006
复制
发表时间：
2004-09-01
影响因子：
4.8
通讯作者：
Siever, LJ
中科院分区：
文献类型：
--
作者：
Koenigsberg, HW;Teicher, MH;Siever, LJ
抑郁症与激素和儿茶酚胺昼夜节律的改变有关。分析这些变化有可能区分抑郁症的三种神经生物学模型，即儿茶酚胺模型、相位提前模型和失调模型。虽然已经报道了一些关于24小时节律的研究，但这些研究结果之间的不一致性使抑郁症时间生物学模型的研究变得复杂。本研究利用24小时内频繁的血浆采样和多振荡器余弦模型来拟合24小时节律。方法：22例抑郁症患者和20例健康对照者在24小时内每隔30分钟采集一次血浆去甲肾上腺素、皮质醇、泌乳素和生长激素，每隔60分钟采集一次血浆MHPG。与健康对照组相比，抑郁症患者的皮质醇，去甲肾上腺素和MHPG的相位提前昼夜节律，皮质醇和催乳素的相位提前半昼夜节律，以及催乳素的相位提前超昼夜节律。此外，与健康对照组相比，抑郁症患者去甲肾上腺素的节律校正24小时平均值（mesor）较低。也有一个较差的优度拟合去甲肾上腺素的昼夜节律振荡器在抑郁症患者相对于健康controls.Conclusions：这些研究结果提供了部分支持抑郁症的失调模型，并与那些研究相一致，发现在抑郁症的皮质醇，去甲肾上腺素和MHPG节奏的阶段进展。爱思唯尔有限公司出版
Depression is associated with alterations in hormone and catecholamine circadian rhythms. Analysis of these alterations has the potential to distinguish between three neurobiological models of depression, the catecholamine model, the phase advance model and the dysregulation model. Although a number of studies of 24-h rhythms have been reported, inconsistencies among the findings have complicated efforts to model the chronobiology of depression. The present study takes advantage of frequent plasma sampling over the 24-h period and a multioscillator cosinor model to fit the 24-h rhythms.Method: Plasma levels of norepinephrine, cortisol, prolacatin and growth hormone were sampled at 30-min intervals, and MHPG at 60-min intervals, over a 24-h period in 22 patients with major depressive disorder and 20 healthy control volunteers.Results: The depressed patients had phase advanced circadian rhythms for cortisol, norepinephrine and MHPG, phase advanced hemicircadian rhythms for cortisol and prolactin, and a phase advanced ultradian rhythm for prolactin compared to healthy control subjects. In addition, the rhythm-corrected 24-h mean value (mesor) of norepinephrine was lower in the depressed patients compared to the healthy controls. There also was a poorer goodness-of-fit for norepinephrine to the circadian oscillator in the depressed patients relative to the healthy controls.Conclusions: These findings provide partial support for the dysregulation model of depression and are consistent with those studies that have found phase advances in cortisol, norepinephrine and MHPG rhythms in depression. Published by Elsevier Ltd.