Functional Connectivity in Late-Life Depression Using Resting-State Functional Magnetic Resonance Imaging
Functional Connectivity in Late-Life Depression Using Resting-State Functional Magnetic Resonance Imaging
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DOI：
10.1097/jgp.0b013e3181cabd0e
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发表时间：
2010-07-01
影响因子：
7.2
通讯作者：
Blamire, Andrew M.
中科院分区：
文献类型：
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作者：
Kenny, Eva R.;O'Brien, John T.;Blamire, Andrew M.
目的：研究是否有晚年抑郁症（LLD）和非抑郁症患者的大脑连接的差异使用的左，右头的尾状核（hCN）作为种子区域。设计：静息状态功能性磁共振成像（fMRI）数据收集使用3特斯拉MRI系统。设置：受试者从纽卡斯尔地区的初级或二级保健服务机构招募。参与者：33名年龄在65岁及以上的受试者; 16名最近有LLD发作的受试者和17名非抑郁受试者。测量值：通过从左和右hCN提取时间信号变化并与大脑的其余部分交叉相关来分析功能连接性。结果如下：在非抑郁组中观察到hCN和额叶区域之间的显著连接，而在LLD中，在更广泛的区域中观察到连接。显示连通性显著增强的区域（p
Objective: To investigate whether there are differences in brain connectivity in late-life depression (LLD) and nondepressed subjects using the left and right heads of caudate nuclei (hCN) as the seed regions. Design: Resting-state functional magnetic resonance imaging (fMRI) data were collected using a 3-Tesla MRI System. Setting: Subjects were recruited from primary or secondary care services in the Newcastle area. Participants: Thirty-three subjects aged 65 years and older; 16 who had a recent episode of LLD and 17 nondepressed subjects. Measurements: Functional connectivity was analyzed by extracting the temporal signal variation from the left and right hCN and cross correlating with the rest of the brain. Results: Significant connectivity between the hCN and frontal areas was observed in the nondepressed group, whereas in LLD, connectivity was seen over a much wider area. Regions showing significantly greater connectivity (p