Gender and ethnicity as moderators: Integrative data analysis of multidimensional family therapy randomized clinical trials.
Gender and ethnicity as moderators: Integrative data analysis of multidimensional family therapy randomized clinical trials.
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DOI：
10.1037/fam0000127
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Liddle HA
中科院分区：
文献类型：
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作者：
Greenbaum PE;Wang W;Henderson CE;Kan L;Hall K;Dakof GA;Liddle HA
这项研究考察了性别和种族作为多维家庭治疗(MDFT)青少年药物滥用有效性的调节变量，并说明了综合数据分析(IDA)在评估适度的有效性方面的作用。通过汇集来自五个独立的MDFT随机临床试验(RCT)的参与者数据，IDA增加了测试适度的能力。研究对象为646名因吸毒而接受治疗的青少年，年龄11至17岁(男性=15.31，SD=1.30)，其中女性占19%(n=126)，欧洲裔占14%(n=92)，西班牙裔占35%(n=225)，非裔美国人占51%(n=329)。参与者被随机分为MDFT或主动对照治疗，这两种治疗方法因研究而异。在研究开始时、6个月和12个月时，通过四个指标的潜在变量来衡量药物使用涉及(即频率和后果)。将来自多个校准样本的生长曲线变化参数与总体治疗效果和主持人分组进行回归。MDFT降低了所有参与者群体的药物使用参与度(P<；0.05)。合并的对照组仅减少了女性和西班牙裔的药物使用(PS<；0.05)。对于男性、非裔美国人和欧洲裔美国人，MDFT比比较更有效(PS<；0.05；Cohen‘s d=1.17、1.95和1.75)。对于女性和西班牙裔，MDFT和合并对照处理之间没有显著差异，Cohen‘s d分别为0.63和0.19。MDFT是一种治疗青少年吸毒的有效方法，无论男女和不同种族，男性、非裔美国人和非西班牙裔白人青少年从MDFT中受益最多。
This study examined gender and ethnicity as moderators of Multidimensional Family Therapy (MDFT) effectiveness for adolescent drug abuse and illustrated the utility of integrative data analysis (IDA,) for assessing moderation. By pooling participant data from five independent MDFT randomized clinical trials (RCTs), IDA increased power to test moderation. Participants were 646 adolescents receiving treatment for drug use, aged 11 to 17 years (M = 15.31, SD = 1.30), with 19% female (n = 126), 14% (n = 92) European American, 35% (n = 225) Hispanic, and 51% (n = 329) African American. Participants were randomized to MDFT or active comparison treatments, which varied by study. Drug use involvement (i.e., frequency and consequences) was measured at study entry, 6-, and 12-months by a four-indicator latent variable. Growth curve change parameters from multiple calibration samples were regressed on treatment effects overall and by moderator subgroups. MDFT reduced drug use involvement (p < .05) for all participant groups. Pooled comparison groups reduced drug use involvement only for females and Hispanics (ps < .05). MDFT was more effective than comparisons for males, African Americans, and European Americans (ps <.05; Cohen's d = 1.17, 1.95, and 1.75, respectively). For females and Hispanics, there were no significant differences between MDFT and pooled comparison treatments, Cohen's d = 0.63 and 0.19, respectively. MDFT is an effective treatment for drug use among adolescents of both genders and varied ethnicity with males, African American, and White Non-Hispanic adolescents benefitting most from MDFT.