The Efficiency of Pulsed Radiofrequency Application on L5 and L6 Dorsal Roots in Rabbits Developing Neuropathic Pain
The Efficiency of Pulsed Radiofrequency Application on L5 and L6 Dorsal Roots in Rabbits Developing Neuropathic Pain
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DOI：
10.1097/aap.0b013e3181c76c21
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发表时间：
2010-01-01
影响因子：
5.1
通讯作者：
Boyaci, Adem
中科院分区：
文献类型：
--
作者：
Aksu, Recep;Ugur, Fatih;Boyaci, Adem
背景：周围神经损伤可能导致神经性疼痛，这是一种对传统疼痛治疗无反应的慢性疼痛。本研究旨在探讨脉冲射频（pulsed radiofrequency，PRF）对兔坐骨神经损伤后L5、L 6背根神经痛的影响。将其分为3组。在第1组和第2组中，用4-0丝线将左侧坐骨神经紧紧地结扎作为部分结扎模型。第3组为假手术组。第1组：42 ℃下脉冲射频消融双侧背根8 min。结果：左侧坐骨神经结扎后10 d，应用PRF前，大鼠出现神经病理性疼痛，热板反应和机械刺激反应，第1组和第2组均低于基础值（P < 0.005）。基线值与第1组兔子在施加PRF 2周后对热板测试或施加RF 3周后对机械刺激的反应之间没有统计学显著差异。结论：PRF能明显减轻神经病理性疼痛引起的痛敏，且与对照组相比，差异有显著性（P < 0.001）。
Background: Injury of a peripheral nerve may lead to neuropathic pain, a form of chronic pain that does not respond to traditional pain therapies. The aim of this study was to investigate the effect of pulsed radiofrequency (PRF) applied to the L5 and L6 dorsal roots oil the neuropathic pain that develops after sciatic nerve injury in rabbits.Methods: In this study, 18 New Zealand rabbits were used. These were divided into 3 groups. In groups 1 and 2, the left sciatic nerve was tightly ligated as a partial ligation model with 4-0 silk Sutures. Group 3 was a sham group. Pulsed radiofrequency was applied to group 1 rabbits oil both dorsal roots at 42 degrees C for 8 mins. The responses of all the groups to thermal and mechanical stimuli were measured for a period of 4 weeks after this process.Results: Ten days after ligation of the left sciatic nerve and before PRF application, neuropathic pain occurred; the responses of groups 1 and 2 to the hot plate test and to the mechanical Stimulus were lower (P < 0.005) when compared with the baseline values. There were no statistically significant differences between baseline values and group 1 rabbits' responses to the hot plate test 2 weeks after the application of PRF or to the mechanical stimulus 3 weeks after RF application. The decrease seen in group 2 persisted after 4 weeks (P < 0.001).Conclusions: The hyperalgesia that develops as a result of neuropathic pain in rabbits was observed to be reduced by PRF application.