Ti nano-nodular structuring for bone integration and regeneration
Ti nano-nodular structuring for bone integration and regeneration
复制标题
DOI：
10.1177/154405910808700809
复制
发表时间：
2008-08-01
影响因子：
7.6
通讯作者：
Ohno, N.
中科院分区：
文献类型：
--
作者：
Ogawa, T.;Saruwatari, L.;Ohno, N.
纳米结构技术已被证明可以在各种生物材料中创造独特的生物学特性。在这里，我们提出了一个发现的现象，发生在物理气相沉积的钛（Ti）到特定条件下的微纹理钛表面的钛纳米结节自组装，并测试一个假设，即钛纳米结构有可能提高骨钛一体化。纳米结构的创建有效地提供了几何底切，并增加了高达40%的表面积相比，酸蚀刻的表面与微观形貌。根据尺寸控制，可以添加纳米节结而不会涂抹现有的微纹理，从而创建纳米-微混合架构。在大鼠股骨模型中，具有560 nm纳米结节的钛植入物产生的骨整合强度是具有酸蚀刻表面的钛植入物的3.1倍。发现的钛纳米结节自结构已被证明在钛以外的生物相容性材料上是可行的，为开发植入物表面和其他可植入材料提供了新的途径，以获得更好的骨生成和再生潜力。
Nanostructuring technology has been proven to create unique biological properties in various biomaterials. Here we present a discovered phenomenon of titanium nano-nodular self-assembly that occurs during physical vapor depositions of titanium (Ti) onto specifically conditioned micro-textured titanium surfaces, and test a hypothesis that the Ti nanostructure has the potential to enhance bone-titanium integration. The nanostructure creation effectively provided geometrical undercut and increased the surface area by up to 40% compared with the acid-etched surface with microtopography. Depending on the size control, the nano-nodules can be added without smearing the existing micro-texture, creating a nano-micro-hybrid architecture. Titanium implants with 560-nm nano-nodules produced 3.1 times greater strength of osseointegration than those with an acid-etched surface in a rat femur model. The discovered titanium nano-nodular self-structuring has been proven feasible on biocompatible materials other than titanium, offering new avenues for the development of implant surfaces and other implantable materials for better bone-generative and -regenerative potential.