Recyclable Heterogeneous Supported Copper-Catalyzed Coupling of Thiols with Aryl Halides: Base-Controlled Differential Arylthiolation of Bromoiodobenzenes
Recyclable Heterogeneous Supported Copper-Catalyzed Coupling of Thiols with Aryl Halides: Base-Controlled Differential Arylthiolation of Bromoiodobenzenes
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DOI：
10.1002/adsc.200900358
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发表时间：
2009-10-01
影响因子：
5.4
通讯作者：
Ranu, Brindaban C.
中科院分区：
文献类型：
--
作者：
Bhadra, Sukalyan;Sreedhar, Bojja;Ranu, Brindaban C.
氧化铝负载的硫酸铜可在有氧、无配体的条件下有效催化芳香族、杂芳香族和脂肪族硫醇与芳基和杂芳基卤化物的 S-芳基化。该方案通过硫醇与芳族卤化物中的碘和溴取代基的碱基控制差异偶联，可以轻松获得各种硫醚以及不对称双硫醚。该催化剂价格低廉、对空气不敏感、环保且可回收。
Alumina-supported copper sulfate efficiently catalyzes the S-arylation of aromatic, heteroaromatic and aliphatic thiols with aryl as well as heteroaryl halides under aerobic, ligand-free conditions. This protocol provides an easy access to a variety of thioethers as well as unsymmetrical bis-thioethers by base-controlled differential coupling of thiols with iodo- and bromo-substituents in an aromatic halide. The catalyst is inexpensive, non-air sensitive, environmentally friendly and recyclable.