Problems of somatic mutation and cancer
Problems of somatic mutation and cancer
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DOI：
10.1002/bies.20000
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发表时间：
2004-03-01
期刊：
影响因子：
4
通讯作者：
Nowak, MA
中科院分区：
文献类型：
--
作者：
Frank, SA;Nowak, MA
体细胞突变在正常细胞转变为癌细胞的过程中起着关键作用。因此，癌症进展的分析需要研究点突变和染色体突变如何在细胞谱系中积累。体细胞突变的传播取决于突变率、细胞谱系历史中的细胞分裂次数以及不同细胞谱系之间竞争的性质。我们考虑组织结构和细胞竞争的各个方面如何影响突变积累的速度。我们还讨论了癌症进展过程中体细胞突变率的上升和下降。 BioEssays 26:291-299, 2004。(C) 2004 Wiley periodicals, Inc.
Somatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a cellular lineage, and the nature of competition between different cellular lineages. We consider how various aspects of tissue architecture and cellular competition affect the pace of mutation accumulation. We also discuss the rise and fall of somatic mutation rates during cancer progression. BioEssays 26:291-299, 2004. (C) 2004 Wiley Periodicals, Inc.